Autoantigenicity of human sperm: molecular identities of sperm antigens recognized by sera of immunoinfertile men in the immunoprecipitation procedure

Archives of Andrology
R K NazC Morte

Abstract

Autoantigenicity of human sperm as related to immunoinfertility was investigated using the immunoprecipitation procedure. Sera from immunoinfertile men specifically immunoprecipitated six specific bands of 135, 95, and 65 kD and double bands of 47, 41, and 23 kD that were not recognized by the sera from fertile men. Of these six specific bands, three bands of 65-, 47-, and 23-kD molecular identities were recognized by > 60% of immunoinfertile sera, and 47 and 23 kD may correspond to the dimeric and monomeric forms of FA-1 antigen, respectively. Seminal plasma from immunoinfertile men specifically recognized three specific bands of 95, 37, and 16 kD; only the 95-kD band was also recognized with the immunoinfertile sera. These specific antigens may find applications in immunocontraception and immunoinfertility in humans.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Aug 1, 1990·American Journal of Obstetrics and Gynecology·R K NazS S Witkin
May 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·S MathurH O Williamson
Nov 1, 1987·The Journal of Clinical Investigation·R K Naz
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Jun 1, 1994·Fertility and Sterility·R K Naz, A C Menge
Nov 1, 1993·The Journal of Clinical Investigation·R K NazA C Menge

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Citations

May 28, 2014·American Journal of Reproductive Immunology : AJRI·Mónica H Vazquez-LevinCarolina Veaute
Jan 1, 1997·American Journal of Reproductive Immunology : AJRI·A B Diekman, J C Herr
Jul 31, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A B DiekmanJ C Herr
Jul 7, 1999·Journal of Reproductive Immunology·J Frayne, L Hall
Jan 9, 1999·Journal of Reproductive Immunology·L E KerrR J Aitken

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