PMID: 2495181Apr 21, 1989Paper

Autocatalytic ftz activation and metameric instability induced by ectopic ftz expression

Cell
D Ish-HorowiczH G Gyurkovics

Abstract

Inappropriate expression of the Drosophila pair-rule gene, fushi tarazu (ftz), causes cuticular pattern deletions apparently complementary to those in ftz larvae. We show that the two patterns actually originate similarly, in both cases affecting the even-numbered parasegmental boundaries. The reciprocal cuticular patterns derive from differing patterns of selector gene expression (homoeotic transformations). The primary effect of ectopic ftz activity is to broaden ftz domains by autocatalytic activation of endogenous ftz expression in an additional anterior cell. This activates engrailed (en) and represses wingless (wg) expression, consistent with their proposed combinatorial control by ftz (and other pair-rule genes) to define parasegmental primordia. We propose that the anterior margin of each ftz stripe is normally defined by the posterior even-skipped (eve) boundary.

References

Jan 23, 1987·Science·J Folkman, M Klagsbrun
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Jan 1, 1986·Annual Review of Cell Biology·M P Scott, P H O'Farrell
Dec 1, 1988·Genes & Development·M FraschM Levine
Jan 1, 1985·Cold Spring Harbor Symposia on Quantitative Biology·D Ish-HorowiczP W Ingham
Feb 21, 1985·Nature·A Martinez-Arias, P A Lawrence
Nov 1, 1984·Cell·R A White, M Wilcox
Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
Nov 1, 1982·Current Genetics·F Meinhardt

❮ Previous
Next ❯

Citations

Aug 26, 1998·Developmental Genetics·P A Lawrence, L Pick
Apr 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S A Newman
Dec 16, 1992·Biochimica Et Biophysica Acta·D Read, J L Manley
Sep 6, 2003·Journal of Theoretical Biology·Lucas Sánchez, Denis Thieffry
Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·F W GeorgeJ D Wilson
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·S J BrownR E Denell
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SuzukiK Umesono
Dec 13, 2005·Evolution & Development·Paul Z Liu, Thomas C Kaufman
Aug 11, 2006·Biochemical and Biophysical Research Communications·Andrew C JamiesonPamela M Carroll
Sep 22, 2001·Current Biology : CB·C R AlonsoM Akam
Apr 28, 2004·Developmental Biology·James B Jaynes, Miki Fujioka
Aug 15, 2009·Developmental Biology·Hui Ying HouLeslie Pick
Sep 26, 2006·Developmental Biology·Timothy BowlerLeslie Pick
Nov 17, 2016·Development Genes and Evolution·Anthony Percival-Smith
Nov 1, 1990·Genes & Development·K A KellermanI Duncan
Sep 1, 1991·Genes & Development·D MorrisseyM Weir
Sep 15, 1995·Genes & Development·M A WelteS Lindquist

❮ Previous
Next ❯