Autocatalytic Morphology Transformation Platform for Targeted Drug Accumulation

Journal of the American Chemical Society
Dong-Bing ChengHao Wang

Abstract

The precise and highly efficient drug delivery of nanomedicines into lesions remains a critical challenge in clinical translational research. Here, an autocatalytic morphology transformation platform is presented for improving the tumor-specific accumulation of drugs by kinetic control. The in situ reorganization of prodrug from nanoparticle to β-sheet fibrous structures for targeted accumulation is based on nucleation-based growth kinetics. During multiple administrations, the autocatalytic morphology transformation can be realized for skipping slow nucleating process and constructing the bulky nanoassembly instantaneously, which has been demonstrated to induce the cumulative effect of prodrug. Furthermore, the sustained drug release from fibrous prodrug depot in the tumor site inhibits the tumor growth efficiently. The autocatalytic morphology transformation strategy in vivo offers a novel perspective for targeted delivery strategy by introducing chemical kinetics and shows great potential in disease theranostics.

References

Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T Gulik-KrzywickiJ Lehn
Jul 11, 2006·Science·Pascal JonkheijmE W Meijer
Sep 20, 2006·Accounts of Chemical Research·Tadato BanYuji Goto
Sep 9, 2008·Biomaterials·Krista L NieceSamuel I Stupp
Apr 20, 2010·Biochimica Et Biophysica Acta·Matthew Biancalana, Shohei Koide
Jun 24, 2010·Nature Chemistry·Joe B GilroyIan Manners
Feb 18, 2014·Journal of the American Chemical Society·Nikolai LorenzenDaniel Erik Otzen
Mar 25, 2014·Journal of Structural Biology·Martin HumenikThomas Scheibel
Sep 23, 2014·The Journal of Physical Chemistry. B·Jonathan BaramBoris Rybtchinski
Sep 9, 2015·Nature Biotechnology·Elvin BlancoMauro Ferrari
Feb 16, 2016·Nature Nanotechnology·Yu MatsumotoKazunori Kataoka
Apr 7, 2016·Journal of the American Chemical Society·Ali NazemiIan Manners
May 15, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yaqin ZhuZhiyuan Zhong
Feb 14, 2017·Journal of the American Chemical Society·Yanbin CaiZhimou Yang
Feb 15, 2017·Advanced Materials·Pei-Pei YangHao Wang
Feb 25, 2017·Advanced Materials·Qihang SunYouqing Shen
Mar 10, 2017·Molecular Pharmaceutics·Hanna B KernPatrick S Stayton
May 10, 2017·Chemistry : a European Journal·Haridas KarSuhrit Ghosh
Aug 8, 2017·Advanced Materials·Guo-Bin QiHao Wang
Oct 11, 2017·Journal of the American Chemical Society·Thomas O MasonAlexander K Buell
Nov 2, 2017·Journal of the American Chemical Society·Boi Hoa SanS Michael Yu
Nov 11, 2017·Nature Reviews. Cancer·Mark W Dewhirst, Timothy W Secomb
Feb 7, 2018·Scientific Reports·Matthew MoldChristopher Exley

❮ Previous
Next ❯

Citations

Jan 9, 2020·Nanoscale·Xinxin LiZhimou Yang
Sep 10, 2020·Advanced Healthcare Materials·Yu DengGaolin Liang
Dec 17, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xiangdong XueYuanpei Li
Jan 1, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sheng ZengDan Ding
Oct 21, 2020·Advanced Drug Delivery Reviews·Ke LiXian-Zheng Zhang
May 20, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Liang Ee LowDaishun Ling
Jun 24, 2021·Journal of the American Chemical Society·Yiheng DaiHuaping Xu
Jul 29, 2021·Biomaterials Science·Ning LiuZhanwei Zhou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved