Autocrine activation by interferon-gamma of STAT factors following T cell activation

European Journal of Immunology
J Girdlestone, M Wing

Abstract

The activation of T cells requires engagement of the T cell receptor/CD3 complex and co-stimulatory molecules, and results in the triggering of several signaling pathways which lead rapidly to the nuclear translocation of several transcription factors, such as nuclear factor (NF)-kappa B and NF-AT. A result of this activation process is the induction of a number of genes, including those encoding cytokines such as interleukin-2, tumor necrosis factor-alpha, and interferon (IFN)-gamma which have important immunoregulatory effects. We report here that a DNA-binding factor containing STAT1 also becomes activated in human peripheral blood T lymphocytes or Jurkat cells, although not until 1-2 h after stimulation. Activation is delayed a further 1-2 hr when mononuclear cell cultures are stimulated by an antigen which requires processing. Appearance of the STAT1 factor is significantly reduced in the presence of cyclosporin A, and blocked by cycloheximide, indicating that its activation is dependent upon a protein(s) synthesized in response to initial signaling events. Neutralizing antiserum against IFN-gamma, but not other cytokines tested, blocked activation of the factor almost completely, and IFN-gamma was found in the culture sup...Continue Reading

References

Nov 1, 1991·European Journal of Immunology·E G RoutledgeH Waldmann
May 1, 1988·European Journal of Immunology·V Bhardwaj, M J Colston
Mar 1, 1995·Immunology Today·M Izquierdo PastorD Cantrell
Jan 1, 1994·Annual Review of Biochemistry·G R Crabtree, N A Clipstone
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J GirdlestoneC Milstein
Jan 28, 1994·Cell·A Weiss, D R Littman

❮ Previous
Next ❯

Citations

Jan 10, 2002·Journal of Neuroscience Research·David R BrownLaura Canevari
May 19, 2001·International Immunopharmacology·N OsnaM M Khan
Oct 19, 2001·International Immunopharmacology·K A ElliottM M Khan
Jun 18, 2003·International Immunopharmacology·Kathleen A Packard, Manzoor M Khan
May 11, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Y P WeiJ Imanishi
Jan 1, 1997·Annual Review of Immunology·U BoehmJ C Howard
Dec 27, 2013·Journal of Neuroimmunology·Wen-I YehLaurie E Harrington
Feb 12, 1998·The Journal of Experimental Medicine·H NeumannH Wekerle
Mar 20, 2014·PloS One·Matthew C ExlineAnasuya Sarkar
May 25, 2016·Clinical Reviews in Allergy & Immunology·Aleš GoropevšekTadej Avčin
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G LombardiA N Akbar
May 22, 2018·Frontiers in Immunology·Flávia CastroMaria José Oliveira
Nov 9, 2019·PLoS Pathogens·Margarida Sanches-VazMiguel Prudêncio
Feb 28, 2020·JCI Insight·Teresa PreglejWilfried Ellmeier
Mar 26, 1999·European Journal of Immunology·D PillingM Salmon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.