Autocrine activation of cultured macrophages by brain-derived neurotrophic factor

Biochemical and Biophysical Research Communications
Toshio AsamiShoei Furukawa

Abstract

To elucidate a significance of the expression of brain-derived neurotrophic factor (BDNF) in the activated microglia/macrophages of the injured central nervous system, we examined BDNF actions on or BDNF synthesis by macrophages cultured from the mouse peritoneal cavity. They synthesized BDNF and neurotrophin-3 (NT-3) in addition to expressing high-affinity neurotrophin receptors, full-length TrkB (FL), truncated TrkB (TK(-)), and TrkC, thus suggesting an autocrine influence of BDNF and NT-3. BDNF, but not NT-3, enhanced phagocytic activity and stimulated synthesis/secretion of interleukin-1beta in the same manner as lipopolysaccharide (LPS). Furthermore, there was a significant correlation of the phagocytic activity with the expression of BDNF or TrkB (FL). These results imply that the phagocytic activity of macrophages depends on BDNF synthesis and/or TrkB (FL) expression, suggesting that BDNF participates in the activation processes of macrophages by acting in an autocrine manner.

References

Nov 1, 1994·Journal of Neurobiology·A M Davies
Jul 1, 1993·Journal of Neurobiology·V Hamburger
Jan 1, 1996·Seikagaku. The Journal of Japanese Biochemical Society·Y FurukawaK Hayashi
Sep 19, 1998·Immunology·O García-SuárezJ A Vega
Nov 11, 1999·Cell and Tissue Research·M Pérez-PérezJ A Vega
Mar 25, 2000·Neurochemistry International·Y L LeeL F Eng
Feb 13, 2001·Journal of Neuroimmunology·M C CaroleoL Aloe
Jun 9, 2001·Journal of Neuroscience Research·R S GhirnikarL F Eng
Jun 19, 2001·Neuroscience Letters·H Kobayashi, A P Mizisin
Jan 7, 2005·Journal of Neuroscience Research·Manabu HashimotoShoei Furukawa
Jan 27, 2005·Neuroreport·Manabu HashimotoShoei Furukawa

❮ Previous
Next ❯

Citations

Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Harris A GelbardHoward E Gendelman
Nov 16, 2007·Journal of Neurotrauma·Kumi Nagamoto-CombsColin K Combs
Mar 23, 2011·Pathology International·Hiromi KashiwazakiRihito Watanabe
Aug 28, 2010·International Journal of Alzheimer's Disease·Erik HjorthMarianne Schultzberg
Aug 19, 2014·International Journal of Cardiology·Jun-Hee HongGoo-Bo Jeong
Jul 3, 2010·Immunobiology·Stephanie LeyBernhard Brüne
Jan 20, 2010·Brain, Behavior, and Immunity·Ira WongXin-Fu Zhou
Nov 18, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hong JiangZhe-Yu Chen
Jan 15, 2008·Clinical and Experimental Immunology·B SamahG Gras
Aug 19, 2011·Alcoholism, Clinical and Experimental Research·Marie-Agnès CostaDominique Malauzat
May 27, 2014·Human Reproduction Update·Matteo MorottiChristian M Becker
Jun 24, 2008·CNS Spectrums·Leah McNallyJonas Hannestad
Dec 31, 2020·Clinical and Translational Medicine·Athanasia WarneckeMario Gimona
Jul 13, 2021·Molecular Biology Reports·Shinya SasakiNoriyoshi Mizuno

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.