Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells

Archives of Toxicology
Kiran RamgolamArmelle Baeza-Squiban

Abstract

Human exposure to PM(2.5) (particulate matter with an aerodynamic diameter below 2.5 μm) is known to be responsible for airway inflammation and may also induce airway remodelling. In respiratory epithelial cells exposed to PM(2.5), releases of pro-inflammatory cytokines such as granulocyte macrophage-colony stimulating factor (GM-CSF) and growth factor ligands of the epidermal growth factor receptor (EGFR) are increased. The present study aimed at determining the involvement of EGFR ligands by autocrine effects in PM(2.5)-induced GM-CSF release. PM(2.5) exposure triggers GM-CSF release by human bronchial epithelial (HBE) cells. This release is dependent on EGFR activation by ligand binding as it is inhibited by AG1478, an inhibitor of EGFR tyrosine kinase activity as well as by a neutralizing anti-EGFR antibody. The use of conditioned medium from cells previously exposed to PM(2.5) demonstrates that PM(2.5)-exposed cells release soluble EGFR ligands able to induce GM-CSF release by an autocrine manner. It was further demonstrated by inhibiting tumour-necrosis factor-alpha converting enzyme (TACE) that is involved in some EGFR ligand shedding. TAPI-2 and GM-6001, two TACE inhibitors, prevented the PM(2.5)-induced GM-CSF release ...Continue Reading

References

Jan 1, 1994·American Journal of Respiratory Cell and Molecular Biology·A L CozensD C Gruenert
Jul 8, 1998·Immunopharmacology and Immunotoxicology·H TakanoM Sagai
Jan 25, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·S BolandF Marano
Jul 2, 2002·American Journal of Respiratory Cell and Molecular Biology·Audrey RichterDonna E Davies
Jul 23, 2002·Trends in Immunology·Stacey A RitzManel Jordana
Aug 10, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·James C Bonner
Feb 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L M HamiltonD E Davies
May 3, 2003·Environmental Health Perspectives·Andrew ChurgJoanne L Wright
May 6, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Augustin BauligArmelle Baeza-Squiban
Jun 20, 2003·Annals of the New York Academy of Sciences·David C LeeLeslie F Jackson
Aug 6, 2003·Free Radical Biology & Medicine·Florence TaoLester Kobzik
Dec 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ning LiAndre E Nel
Jan 1, 2004·American Journal of Respiratory Cell and Molecular Biology·Sophie BlanchetArmelle Baeza-Squiban
Jan 28, 2004·Inhalation Toxicology·Andrew J Ghio, Yuh-Chin T Huang
Jan 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Matt X G Shao, Jay A Nadel
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Shigeru OkumuraYoshimichi Okayama
Feb 8, 2005·The Journal of Allergy and Clinical Immunology·Shen-Wu WangZhengbin Yao
Jul 9, 2005·Environmental Health Perspectives·Günter OberdörsterJan Oberdörster
Aug 23, 2005·Proceedings of the American Thoracic Society·Peter K Jeffery
Jan 21, 2006·American Journal of Respiratory Cell and Molecular Biology·S Marina Casalino-MatsudaRosanna M Forteza
Feb 3, 2006·The European Respiratory Journal·A F BehndigA Blomberg
Mar 9, 2006·JAMA : the Journal of the American Medical Association·Francesca DominiciJonathan M Samet
Mar 18, 2006·American Journal of Respiratory Cell and Molecular Biology·Tomasz K BaginskiDavid C Swinney
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Augustin BauligArmelle Baeza-Squiban
Sep 7, 2007·The European Respiratory Journal·M RumelhardA Baeza-Squiban
Dec 13, 2007·The Journal of Allergy and Clinical Immunology·Stephen T Holgate
Oct 2, 2008·The European Respiratory Journal·P-R Burgel, J A Nadel
Jul 28, 2009·Particle and Fibre Toxicology·Anne B KnolGerard Hoek
Nov 10, 2009·The Journal of Allergy and Clinical Immunology·Yukinori EnomotoYoshimichi Okayama
Apr 10, 2010·American Journal of Respiratory Cell and Molecular Biology·Takashi KidoStephan F Van Eeden
Oct 22, 2010·Environmental Health Perspectives·Jason D SacksMary Ross
Jan 13, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Timothy D Le CrasGurjit K Khurana Hershey
Sep 10, 2011·Journal of Applied Physiology·Elizabeth L KramerTimothy D Le Cras

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Citations

Jul 24, 2012·Archives of Toxicology·Stéphanie ValArmelle Baeza-Squiban
Dec 24, 2014·Immunobiology·Joost van TongerenCornelis M van Drunen
May 18, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K C De GroveT Maes

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