Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production

European Journal of Immunology
C DemangelW J Britton

Abstract

The production of IL-12 by dendritic cells (DC) early in an immune response is considered critical for the polarization of CD4(+) T lymphocyte response towards a Th1 pattern, a key process in the clearance of intracellular pathogens. Infection of bone marrow-derived DC with Mycobacterium bovis Bacillus Calmette Guérin (BCG) induced a concurrent and dose-dependent releaseof IL-10 and IL-12. Here we examined whether the production of IL-10 by DC affected their IL-12 response to mycobacterial infection and the generation of protective immune responses in vivo. Compared to wild-type (WT) DC, DC deficient for IL-10 synthesis (IL-10(-/-)) showed increased IL-12 production in response to BCG infection and CD40 stimuli in vitro. Moreover, when transferred into mice, infected IL-10(-/-) DC were more efficient than WT DC at inducing IFN-gamma production to mycobacterial antigens in the draining lymph nodes (DLN). This effect was associated with increased trafficking of IL-10(-/-) DC to the DLN and enhanced IL-12 production by DC within the DLN. These data show that autocrine IL-10 exerts a dual inhibitory effect on the induction of primary immune responses by DC: first, by down-regulating the migration of infected DC to the DLN and secon...Continue Reading

References

Dec 1, 1993·The Journal of Experimental Medicine·J L FlynnB R Bloom
Aug 1, 1994·European Journal of Immunology·A W HeathM C Howard
Nov 1, 1993·American Journal of Respiratory Cell and Molecular Biology·C E HavenithE C Hoefsmit
Mar 1, 1993·American Journal of Respiratory Cell and Molecular Biology·C E HavenithE C Hoefsmit
May 1, 1997·European Journal of Immunology·T De SmedtM Moser
Jun 16, 1997·The Journal of Experimental Medicine·E IngulliM K Jenkins
Oct 2, 1998·Advances in Immunology·G Trinchieri
May 25, 1999·Infection and Immunity·P J Murray, R A Young
Aug 17, 1999·Current Opinion in Immunology·C Reis e SousaP Kaye
Nov 5, 1999·Nature Medicine·J M Austyn
Feb 19, 2000·Current Opinion in Immunology·K V Anderson
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J U IgietsemeC M Black
Aug 18, 2000·Immunology and Cell Biology·C Demangel, W J Britton
Oct 4, 2000·Experimental Dermatology·A D McLellanE Kämpgen
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S Thoma-UszynskiR L Modlin
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M M Kane, D M Mosser
Mar 13, 2001·Annual Review of Immunology·J L Flynn, J Chan
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S CorintiG Girolomoni
Apr 5, 2001·Trends in Immunology·B PulendranC Maliszewski
Jul 6, 2001·Scandinavian Journal of Immunology·D R RoachW J Britton

❮ Previous
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Citations

Dec 14, 2004·European Journal of Immunology·Gerben BoumaMarjan A Versnel
Mar 17, 2007·Journal of Clinical Immunology·Kamlesh Bhatt, Padmini Salgame
Jan 30, 2004·Cytokine & Growth Factor Reviews·Simone MocellinMario Lise
Sep 5, 2003·The Lancet Infectious Diseases·JoAnn M TufarielloJoAnne L Flynn
Mar 10, 2010·Immunology and Cell Biology·Adelheid Elbe-Bürger, Christopher Schuster
Jan 11, 2007·Immunology and Cell Biology·Bernadette M Saunders, Warwick J Britton
Jan 22, 2003·Immunology and Cell Biology·Warwick J Britton, Umaimainthan Palendira
Sep 13, 2002·Immunology and Cell Biology·Lois L Cavanagh, Ulrich H Von Andrian
Jul 28, 2009·AIDS Research and Human Retroviruses·L BuonaguroF M Buonaguro
Jul 12, 2011·The Journal of Infectious Diseases·Ronit Cohen-PoradosuDennis L Kasper
Mar 24, 2009·Annual Review of Immunology·Andrea M Cooper
Dec 20, 2012·Pulmonary Medicine·Yone Vila Nova CavalcantiValéria Rêgo Alves Pereira
Nov 20, 2002·The Journal of Clinical Investigation·Stephanie L ConstantKim Bottomly
Nov 13, 2009·The Journal of Clinical Investigation·Denis BedoretFabrice Bureau
Oct 22, 2003·The Journal of Experimental Medicine·Gianluca RottaMaria Rescigno
Feb 1, 2005·Journal of Virology·Dupeh R PalmerTimothy Burgess
Feb 25, 2005·The Journal of Experimental Medicine·Claudia Traidl-HoffmannHeidrun Behrendt
Jul 5, 2006·The Journal of Experimental Medicine·Shabaana A KhaderAndrea M Cooper
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Judy DayLarry S Schlesinger
Aug 5, 2009·Infection and Immunity·Nicole N DriessenBen J Appelmelk
Oct 22, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Zhugong LiuWilliam C Gause
Apr 6, 2011·PloS One·Gerco den HartogR J Joost van Neerven
Oct 6, 2005·Journal of Leukocyte Biology·Simone MocellinHoward A Young
Sep 18, 2004·European Journal of Immunology·Francesco DieliAlfredo Salerno
Jun 16, 2004·Journal of Leukocyte Biology·Souyet Chang-RodriguezAdelheid Elbe-Bürger
Sep 16, 2011·Cancer Immunology, Immunotherapy : CII·Cailin Moira WilkeWeiping Zou
May 30, 2003·Pharmacological Reviews·K AsadullahH D Volk
Feb 4, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew G LassenYoung S Hahn
Mar 6, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens SchreinerStella E Autenrieth
Mar 21, 2017·Journal of Immunology Research·José M RojasNoemí Sevilla
May 19, 2018·The Journal of Experimental Medicine·Jeremy P HuynhChristina L Stallings

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