PMID: 9533771Apr 9, 1998Paper

Autocrine motility factor and the extracellular matrix. I. Coordinate regulation of melanoma cell adhesion, spreading and migration involves focal contact reorganization

International Journal of Cancer. Journal International Du Cancer
S SillettiA Raz

Abstract

Cellular interactions with the extracellular matrix are complex and are involved in numerous biological processes. These interactions may be modulated by cytokines such as tumor cell autocrine motility factor, a secreted molecule that regulates cellular growth and migration by a receptor-mediated pathway. In this report we provide evidence suggesting that high- and low-metastatic K1735 melanoma cells coordinate their attachment, spreading and migratory responses to autocrine motility factor and the extracellular substratum through alterations in focal adhesion plaque architecture that are dependent on both inherent cellular metastatic phenotype and the composition of the supporting matrix. Thus, since activation of the autocrine motility factor receptor has previously been shown to enhance the experimental metastasis of the high- but not the low-metastatic K1735 cells, differences in melanoma cell malignancy in this system may be due in part to a coordinated interplay between cytokine-mediated responses and extracellular matrix-directed regulation of cellular adhesion, spreading and motility.

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Citations

Aug 5, 2015·Journal of Experimental & Clinical Cancer Research : CR·Zhongping ChengXiaoyan Qu
Sep 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wenliang QiaoQiang Lin
Aug 11, 2015·Molecular Carcinogenesis·Zhongping ChengXiaoyan Qu
Aug 22, 2000·Nature·A Ridley
Dec 25, 2003·In Vitro Cellular & Developmental Biology. Animal·Luis G Quiñones, Ivette Garcia-Castro
Jul 25, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David J HeidenreichPhilip R Brauer

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