Abstract
Cellular interactions with the extracellular matrix are complex and are involved in numerous biological processes. These interactions may be modulated by cytokines such as tumor cell autocrine motility factor, a secreted molecule that regulates cellular growth and migration by a receptor-mediated pathway. In this report we provide evidence suggesting that high- and low-metastatic K1735 melanoma cells coordinate their attachment, spreading and migratory responses to autocrine motility factor and the extracellular substratum through alterations in focal adhesion plaque architecture that are dependent on both inherent cellular metastatic phenotype and the composition of the supporting matrix. Thus, since activation of the autocrine motility factor receptor has previously been shown to enhance the experimental metastasis of the high- but not the low-metastatic K1735 cells, differences in melanoma cell malignancy in this system may be due in part to a coordinated interplay between cytokine-mediated responses and extracellular matrix-directed regulation of cellular adhesion, spreading and motility.
References
Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·L H RomerC E Turner
Nov 11, 1992·The Journal of Dermatology·T EtohM C Mihm
Aug 1, 1992·Journal of Cellular Physiology·B ElliottK Rubin
Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·E RuoslahtiW A Border
Apr 1, 1990·The Journal of Cell Biology·S AznavoorianL A Liotta
Jan 1, 1987·Annual Review of Cell Biology·G R Martin, R Timpl
Jul 25, 1986·Science·M J HumphriesK M Yamada
Feb 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·B A GilchrestM Yaar
Jul 1, 1995·Experimental Cell Research·G Scott, H Liang
Oct 12, 1995·Nature·D IlićT Yamamoto
Jan 1, 1995·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·G N van MuijenD J Ruiter
Jul 1, 1995·Experimental Cell Research·A MelchioriA Albini
Jan 1, 1993·Clinical & Experimental Metastasis·L A RepeshJ B McCarthy
Feb 3, 1993·Journal of the National Cancer Institute·G TarabolettiV Castronovo
Mar 15, 1996·International Journal of Cancer. Journal International Du Cancer·J Heino
Jun 1, 1992·Trends in Cell Biology·F Van Roy, M Mareel
May 13, 2008·Pathology Oncology Research : POR·S SillettiA Raz
Citations
Feb 9, 2002·British Journal of Pharmacology·M C ChangJ H Jeng
Nov 1, 2008·PloS One·Liliana D KojicIvan R Nabi
Aug 5, 2015·Journal of Experimental & Clinical Cancer Research : CR·Zhongping ChengXiaoyan Qu
Sep 24, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wenliang QiaoQiang Lin
Jul 16, 2009·Molecular BioSystems·Maria FairbankIvan R Nabi
Aug 11, 2015·Molecular Carcinogenesis·Zhongping ChengXiaoyan Qu
Nov 18, 2015·Molecular Medicine Reports·Zhong WuFan Zhang
Aug 22, 2000·Nature·A Ridley
Aug 22, 2000·Nature·M BittnerV Sondak
Dec 25, 2003·In Vitro Cellular & Developmental Biology. Animal·Luis G Quiñones, Ivette Garcia-Castro
Apr 16, 2015·Oncology Reports·Jing GuoZhongping Cheng
Jul 25, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David J HeidenreichPhilip R Brauer