PMID: 9533772Apr 9, 1998Paper

Autocrine motility factor and the extracellular matrix. II. Degradation or remodeling of substratum components directs the motile response of tumor cells

International Journal of Cancer. Journal International Du Cancer
S SillettiA Raz

Abstract

Autocrine motility factor is a tumor-secreted cytokine which regulates cellular growth and motility by a receptor-mediated pathway. In the accompanying report (Part I of II), it was demonstrated that high (K1735-M1) and low (K1735-C1.11) metastatic murine melanoma cells display distinct adhesion and spreading characteristics which correlate with their differential spontaneous and stimulated migrations on the extracellular matrix components fibronectin, laminin and collagen IV. These parameters were further related to discrete profiles of focal adhesion plaque integrity and reorganization. Here we describe unique migration patterns observed in these murine melanoma cells which reflect differences in degradation and/or remodeling of the cellular substratum. These profiles of matrix interaction were influenced distinctly by autocrine motility factor and dictated by both substrate composition and cellular phenotype. Since activation of the autocrine motility factor receptor stimulates invasion of a reconstituted basement membrane and enhances experimental metastasis by high- but not low-metastatic K1735 cells, differences in the invasive phenotypes of these cells may be due in part to their differential responses to external stimul...Continue Reading

References

Jan 1, 1982·Cancer Metastasis Reviews·L A LiottaS Garbisa
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Citations

Jul 25, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David J HeidenreichPhilip R Brauer
Apr 27, 2001·Seminars in Cancer Biology·A M Mercurio, I Rabinovitz
Dec 25, 2003·In Vitro Cellular & Developmental Biology. Animal·Luis G Quiñones, Ivette Garcia-Castro
Jun 12, 2013·Clinical & Experimental Metastasis·Yu ZhangMaria Marjorette O Peña

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