Autocrine regulation of IL-21 production in human T lymphocytes

The Journal of Immunology : Official Journal of the American Association of Immunologists
Flavio CaprioliGiovanni Monteleone

Abstract

IL-21 has pathologic function in immune-inflammatory diseases. IL-21 mediates its functions through a heterodimeric receptor, composed of a specific subunit, termed IL-21R, and the common gamma-chain. IL-21 is mostly produced by CD4(+) T cells, but molecular mechanisms that regulate IL-21 synthesis are not fully understood. The fact that CD4(+) T cells express high levels of IL-21R and are capable of functionally responding to IL-21 raises the possibility that IL-21 may regulate its own production. We here show that IL-21 enhances IL-21 RNA and protein expression in human peripheral blood CD3(+) T cells in a dose- and time-dependent fashion. Additionally, both IL-7 and IL-15, but not IL-4, induce IL-21, thus suggesting that common gamma-chain signals are not sufficient to promote IL-21 synthesis. Analysis of molecular mechanisms underlying IL-21 induction reveals that IL-21 activates Stat3 and enhances its recruitment to IL-21 gene promoter. Pharmacologic inhibition and knockdown of Stat3 by small interference RNA largely prevent IL-21 induction in IL-21-treated cells. Consistently, IL-21 is inducible in T cells by IL-6, another cytokine that activates Stat3. Finally, we show that IL-21 positively regulates its own expression i...Continue Reading

References

Jul 3, 1998·Gastroenterology·C Fiocchi
Apr 25, 2000·Annual Review of Medicine·K A Papadakis, S R Targan
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·K OzakiW J Leonard
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H AsaoK Sugamura
May 30, 2002·Nature Reviews. Immunology·Marc Feldmann
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mari StrengellSampsa Matikainen
Nov 26, 2002·Science·Katsutoshi OzakiWarren J Leonard
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mari StrengellTimo Sareneva
Jun 5, 2004·Journal of Leukocyte Biology·Mari StrengellSampsa Matikainen
Nov 18, 2004·Immunological Reviews·Devangi S MehtaMichael J Grusby
Jan 5, 2005·The Journal of Experimental Medicine·Rong ZengWarren J Leonard
Sep 3, 2005·Nature Reviews. Immunology·Warren J Leonard, Rosanne Spolski
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akira SutoMichael J Grusby
Dec 21, 2006·Nature Immunology·Eric H LiuJohn J O'Shea
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ilaria PelusoGiovanni Monteleone
Jan 16, 2007·Annual Review of Medicine·Theresa T Pizarro, Fabio Cominelli
Jan 20, 2007·Blood·Rong ZengWarren J Leonard
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Deborah HerberKyri Dunussi-Joannopoulos
Mar 22, 2007·Nature Immunology·Estelle BettelliVijay K Kuchroo
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roberta CarusoGiovanni Monteleone
May 15, 2007·Lancet·Daniel C Baumgart, William J Sandborn
May 26, 2007·Nature Reviews. Immunology·Iain B McInnes, Georg Schett
Jun 8, 2007·Journal of Leukocyte Biology·Valérie OstiguyNathalie Labrecque

❮ Previous
Next ❯

Citations

Oct 23, 2009·Tissue Antigens·H Søndergaard, K Skak
Mar 24, 2010·Immunology and Cell Biology·Hideki UenoJacques Banchereau
Dec 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tiehui WangChristopher J Secombes
Mar 8, 2011·Inflammatory Bowel Diseases·Gheorghe HundorfeanJonas Mudter
Dec 8, 2011·Arthritis and Rheumatism·Benjamin TerrierPatrice Cacoub
Jul 13, 2012·Mucosal Immunology·M SarraG Monteleone
Feb 15, 2013·Korean Circulation Journal·Mi Hyun KimHae Yong Lee
Apr 5, 2013·BioFactors·Massimiliano SarraGiovanni Monteleone
May 14, 2016·Expert Opinion on Investigational Drugs·Roberta IzzoGiovanni Monteleone
Oct 22, 2018·Journal of Cellular Physiology·Hassan El-SaidBassam Badran
Feb 7, 2009·Expert Review of Vaccines·Luiz Rodrigues, Cristina Bonorino
Jul 3, 2010·Expert Review of Clinical Immunology·Francesco PalloneGiovanni Monteleone
Oct 24, 2009·Nature Reviews. Cancer·Hua YuRichard Jove
Aug 4, 2012·The Journal of Rheumatology·Benjamin TerrierPatrice Cacoub
Mar 19, 2013·European Journal of Immunology·Nathalie MariFabienne Andris
Dec 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Barbara LeibigerPer-Olof Berggren
Apr 27, 2018·Journal of Crohn's & Colitis·Giulia NizzoliFederica Facciotti
Oct 17, 2018·Frontiers in Immunology·Qin ZengTuo Deng
Aug 16, 2018·Frontiers in Oncology·Emira Bousoik, Hamidreza Montazeri Aliabadi
Dec 17, 2010·Journal of Virology·LaTonya D WilliamsPaul A Goepfert
Feb 27, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ashok Kumar Pandurangan, Norhaizan Mohd Esa
Mar 3, 2009·Inflammatory Bowel Diseases·Clara Abraham, Judy Cho
Dec 31, 2014·Journal of Leukocyte Biology·Kathleen O Busman-SahayWilliam O'Connor
Feb 27, 2010·Inflammatory Bowel Diseases·Massimiliano SarraGiovanni Monteleone
Aug 9, 2016·Rheumatology·Noémie GensousPatrick Blanco
Apr 17, 2020·Klinicheskaia laboratornaia diagnostika·A I MalyshkinaE V Kozelkova
Jan 24, 2009·Immunological Reviews·Lynette A FouserMary Collins
Aug 18, 2009·Nature Medicine·Roberta CarusoGiovanni Monteleone
May 25, 2016·Clinical Reviews in Allergy & Immunology·Aleš GoropevšekTadej Avčin
Oct 17, 2014·Current Opinion in Pediatrics·Daniel KotlarzChristoph Klein
Nov 4, 2008·Annual Review of Medicine·Clara Abraham, Judy H Cho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Inflammation & Allergy Drug Targets
Daniele FinaGiovanni Monteleone
Inflammation & Allergy Drug Targets
Massimiliano SarraGiovanni Monteleone
The Journal of Immunology : Official Journal of the American Association of Immunologists
Ilaria PelusoGiovanni Monteleone
© 2021 Meta ULC. All rights reserved