Autocrine stimulation of rhadinovirus-transformed T cells by the chemokine CCL1/I-309

Oncogene
Gültekin TamgüneyHelmut Fickenscher

Abstract

The rhadinovirus herpesvirus saimiri transforms human T lymphocytes to stable growth in culture. Besides the viral oncogenes stpC and tip, little is understood about the transformation process at the cellular level. To identify cellular factors that might contribute to growth transformation, we compared cellular gene expression in pairs of herpesvirus saimiri-transformed and nontransformed human T-cell clones. Using cDNA arrays and suppressive subtractive hybridization, we were able to identify the chemokine CCL1/I-309 as one of the few cellular genes that are strongly overexpressed in T cells after growth transformation with herpesvirus saimiri. The transformed T cells expressed CCR8, the receptor for CCL1, which rapidly induced intracellular calcium ion levels. Neutralizing antibodies to CCL1 led to reduced secretion of interferon-gamma and tumor necrosis factor-alpha as well as to reduced proliferation rates in transformed T cells. Thus, we propose that growth transformation of human T cells with herpesvirus saimiri gives rise to an autocrine loop where the proliferation of transformed T cells is supported by the endogenous production of the chemokine CCL1.

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B BiesingerB Fleckenstein
Sep 1, 1992·The Journal of Experimental Medicine·H W MittrückerB Fleischer
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J C RenauldJ Van Snick
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M D Miller, M S Krangel
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J U JungR C Desrosiers
Dec 1, 1991·Journal of Virology·J U Jung, R C Desrosiers
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y YamanashiK Toyoshima
Dec 1, 1995·The Journal of Experimental Medicine·G Del PreteS Romagnani
Sep 1, 1995·The Journal of Biological Chemistry·J U JungB Biesinger
Feb 1, 1994·International Journal of Cancer. Journal International Du Cancer·B TroidlE Gebhart
Jan 1, 1993·Archives of Virology
Dec 1, 1995·Molecular and Cellular Biology·J U Jung, R C Desrosiers
Jan 12, 1996·The Journal of Biological Chemistry·N WieseB M Bröker
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·L DiatchenkoP D Siebert
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·C MollereauM Parmentier
Oct 23, 1996·Biochemical and Biophysical Research Communications·A ZaballosG Márquez
Mar 1, 1997·Clinical Immunology and Immunopathology·C E MackewiczJ A Levy
Jan 28, 1998·Journal of Virology·S M DuboiseJ U Jung
Jan 6, 2000·The Journal of Experimental Medicine·H R LüttichauT W Schwartz
Apr 5, 2000·The Journal of Biological Chemistry·D A Hartley, G M Cooper
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M InngjerdingenA A Maghazachi
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S SebastianiA Cavani
Mar 13, 2001·DNA and Cell Biology·L E WehnerU Rüther
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Fickenscher, B Fleckenstein
Apr 4, 2002·Trends in Immunology·Helmut FickenscherHeinrich Sticht
Jan 15, 2003·Journal of Leukocyte Biology·Gaia SpinettiMonica Napolitano
Mar 21, 2003·European Journal of Immunology·Jamila LouahedJean-Christophe Renauld
Jul 9, 2003·Genes and Immunity·S E B GraefeB Fleischer

❮ Previous
Next ❯

Citations

Jul 24, 2013·The Journal of Experimental Medicine·Suvendu DasMihaela Skobe
Jun 15, 2005·Journal of Translational Medicine·David F StroncekMonica C Panelli
Oct 5, 2017·World Journal of Gastroenterology : WJG·Renate S OlsenDick Wågsäter
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akiyoshi HoshinoTaeko Dohi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.