Abstract
Transforming growth factor beta (TGF-beta) has been extensively studied as an exogenous agent that stimulates the expression of extracellular matrix proteins and their cell-surface integrin receptors in a variety of cell types. However, the recent demonstration of autocrine TGF-beta growth effects in a number of cell types suggests that the steady-state expression of extracellular matrix and integrin proteins and their biological activity may also be under autocrine TGF-beta control. Previously, we reported that repression of autocrine TGF-beta 1 activity by constitutive expression of a full-length TGF-beta 1 antisense cDNA led to abrogation of autocrine negative TGF-beta and, as a result, increased tumorigenicity and anchorage-independent growth of a poorly tumorigenic, well-differentiated colon carcinoma cell line designated FET (Wu, S., Theodorescu, D., Kerbel, R. S., Willson, J. K. V., Mulder, K. M., Humphrey, L. E., and Brattain, M. G. (1992) J. Cell Biol. 116, 187-196). Consequently, we have used this model system to study the effects of repression of autocrine TGF-beta 1 activity on the expression of integrin alpha 5 beta 1 and integrin alpha 5 beta 1-mediated cell adhesion to fibronectin. The expression of the integrin ...Continue Reading
References
Nov 27, 1979·Biochemistry·J M ChirgwinW J Rutter
Jun 1, 1992·Journal of Cellular Physiology·M F JanatG Liau
Mar 1, 1992·Kidney International·A B RobertsM B Sporn
Jan 1, 1992·The Journal of Cell Biology·S P WuM G Brattain
Nov 1, 1991·Journal of Cellular Physiology·S B MilamR J Klebe
Jan 1, 1991·The Journal of Clinical Investigation·E Ruoslahti
Aug 1, 1990·Cell Regulation·B E Symington
Mar 9, 1990·Cell·F G Giancotti, E Ruoslahti
Jan 1, 1990·Annals of the New York Academy of Sciences·M B Sporn, A B Roberts
Jan 1, 1990·Annals of the New York Academy of Sciences·A B RobertsR Lechleider
Jan 27, 1989·Cell·L C Plantefaber, R O Hynes
Apr 1, 1989·Experimental Cell Research·N M HooseinM G Brattain
Aug 1, 1989·The Journal of Cell Biology·Z WerbC H Damsky
Oct 23, 1987·Cell·R A Ignotz, J Massagué
Oct 4, 1984·Nature·M E Greenberg, E B Ziff
Jan 1, 1984·Cancer Metastasis Reviews·M G BrattainB Long
Dec 16, 1983·Journal of Immunological Methods·T Mosmann
Sep 1, 1995·Journal of Cellular Physiology·D WangL Sun
Sep 1, 1994·Experimental Cell Research·L SunM G Brattain
Sep 1, 1993·Cancer Metastasis Reviews·G M HowellM G Brattain
Jan 1, 1993·The Journal of Cell Biology·C H StreuliR Derynck
Citations
Jun 9, 1998·Journal of Cellular Physiology·C SudarshanR Raghow
Feb 14, 2006·Clinical & Experimental Metastasis·Kouji KatabamiTsutomu Tsuji
Jun 25, 1998·In Vitro Cellular & Developmental Biology. Animal·N RahimiB Elliott
May 17, 2006·Anti-cancer Drugs·Eleonora PagnottaLanfranco Masotti
Mar 24, 2012·Pancreas·Naoteru MiyataToshifumi Hibi
Jul 11, 1998·Journal of Periodontology·D A Tipton, M K Dabbous
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·S R AmorosoJ J Letterio
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S ZhouB Vogelstein
Jun 23, 2015·Journal of Functional Biomaterials·Desiree ' LyonDimitrios Karamichos
Nov 29, 2005·Cellular Microbiology·Emmanuelle TixierMichel Neunlist
Jun 9, 2005·Reproductive Biology and Endocrinology : RB&E·Anne DamestoyPhilippe Durand
Jul 21, 2004·BMC Genomics·Shanaz H DairkeeStefanie S Jeffrey
Dec 17, 2009·PloS One·Barbara JungJohn M Carethers
May 3, 1996·The Journal of Biological Chemistry·C Le RoyD Langlois
Jan 16, 2002·Oncogene·Stephen W TobinBradley A Arrick
Nov 7, 2007·Genes, Chromosomes & Cancer·Swati BiswasWilliam M Grady
Jun 1, 2000·Growth Factors·N Pouliot, A W Burgess
Feb 19, 1999·Oncogene·H ShengR D Beauchamp
Apr 23, 1999·The Journal of Biological Chemistry·D WangM G Brattain
Oct 4, 1996·The Journal of Biological Chemistry·D J WebbS L Gonias
Oct 31, 2001·The Journal of Biological Chemistry·Rajinder S SawhneyMichael G Brattain
Dec 22, 1995·The Journal of Biological Chemistry·A M WeaverS L Gonias
Jan 5, 2002·Journal of Virology·Terry JacksonAndrew M Q King
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A VenutiA Bagnato
Oct 16, 2010·International Journal of Cancer. Journal International Du Cancer·Yue HongBadar A Usmani
Jul 3, 2013·International Journal of Cancer. Journal International Du Cancer·Brahim AissaniLisa P Jacobson
Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·B K BolesJ Roman
Oct 31, 2003·The Journal of Biological Chemistry·Loredana MoroMargherita Greco
May 23, 2018·International Journal of Molecular Medicine·Takuya KuwashiroIwata Ozaki
Oct 9, 1999·The Journal of Biological Chemistry·S L DaltonR K Assoian
Oct 20, 1999·Gynecologic Oncology·N ChattopadhyayA Chatterjee
May 11, 1999·Differentiation; Research in Biological Diversity·S ThorsteinsdóttirC L Mummery
Aug 23, 1996·Cell·W CuiR J Akhurst
Sep 18, 2002·European Journal of Cell Biology·Jae Youn YiYoung Sook Son