Autocrine transforming growth factor beta 1 modulates the expression of integrin alpha 5 beta 1 in human colon carcinoma FET cells.

The Journal of Biological Chemistry
D WangM G Brattain

Abstract

Transforming growth factor beta (TGF-beta) has been extensively studied as an exogenous agent that stimulates the expression of extracellular matrix proteins and their cell-surface integrin receptors in a variety of cell types. However, the recent demonstration of autocrine TGF-beta growth effects in a number of cell types suggests that the steady-state expression of extracellular matrix and integrin proteins and their biological activity may also be under autocrine TGF-beta control. Previously, we reported that repression of autocrine TGF-beta 1 activity by constitutive expression of a full-length TGF-beta 1 antisense cDNA led to abrogation of autocrine negative TGF-beta and, as a result, increased tumorigenicity and anchorage-independent growth of a poorly tumorigenic, well-differentiated colon carcinoma cell line designated FET (Wu, S., Theodorescu, D., Kerbel, R. S., Willson, J. K. V., Mulder, K. M., Humphrey, L. E., and Brattain, M. G. (1992) J. Cell Biol. 116, 187-196). Consequently, we have used this model system to study the effects of repression of autocrine TGF-beta 1 activity on the expression of integrin alpha 5 beta 1 and integrin alpha 5 beta 1-mediated cell adhesion to fibronectin. The expression of the integrin ...Continue Reading

References

Mar 1, 1992·Kidney International·A B RobertsM B Sporn
Nov 1, 1991·Journal of Cellular Physiology·S B MilamR J Klebe
Jan 1, 1991·The Journal of Clinical Investigation·E Ruoslahti
Jan 1, 1990·Annals of the New York Academy of Sciences·M B Sporn, A B Roberts
Jan 1, 1990·Annals of the New York Academy of Sciences·A B RobertsR Lechleider
Jan 27, 1989·Cell·L C Plantefaber, R O Hynes
Jan 1, 1984·Cancer Metastasis Reviews·M G BrattainB Long
Sep 1, 1993·Cancer Metastasis Reviews·G M HowellM G Brattain
Jan 1, 1993·The Journal of Cell Biology·C H StreuliR Derynck

❮ Previous
Next ❯

Citations

Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·S R AmorosoJ J Letterio
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S ZhouB Vogelstein
Jun 23, 2015·Journal of Functional Biomaterials·Desiree ' LyonDimitrios Karamichos
Jun 9, 2005·Reproductive Biology and Endocrinology : RB&E·Anne DamestoyPhilippe Durand
Jul 21, 2004·BMC Genomics·Shanaz H DairkeeStefanie S Jeffrey
Apr 23, 1999·The Journal of Biological Chemistry·D WangM G Brattain
Jan 5, 2002·Journal of Virology·Terry JacksonAndrew M Q King
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A VenutiA Bagnato
Oct 16, 2010·International Journal of Cancer. Journal International Du Cancer·Yue HongBadar A Usmani
Jul 3, 2013·International Journal of Cancer. Journal International Du Cancer·Brahim AissaniLisa P Jacobson
Apr 6, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·B K BolesJ Roman
Oct 31, 2003·The Journal of Biological Chemistry·Loredana MoroMargherita Greco
May 23, 2018·International Journal of Molecular Medicine·Takuya KuwashiroIwata Ozaki
Oct 20, 1999·Gynecologic Oncology·N ChattopadhyayA Chatterjee
Sep 18, 2002·European Journal of Cell Biology·Jae Youn YiYoung Sook Son

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.