Autofluorescence endoscopy: feasibility of detection of GI neoplasms unapparent to white light endoscopy with an evolving technology

Gastrointestinal Endoscopy
J HaringsmaR W Cline

Abstract

Case studies are presented of fluorescence endoscopy in the upper and lower GI tract to illustrate the ability to detect early-stage lesions that were not observable with white light endoscopy or those in which the assessment of the stage or extension of the lesion were equivocal. A new fluorescence imaging system was used in which blue light excites the naturally-occurring fluorescence of tissues (autofluorescence). The system produces real-time, false-color images that combine green and red fluorescence intensities. In general, abnormal lesions are seen to have an increase in the red-to-green fluorescence intensity compared with surrounding tissue. This system was evaluated in patients at 4 participating institutions, concurrently with standard white light endoscopy, with or without dye staining. Selected cases are presented in which fluorescence imaging identified specific lesions including focal high-grade dysplasia in Barrett's mucosa, signet ring carcinoma of the stomach, and flat adenoma in the colon. The capability of autofluorescence endoscopy to detect the presence and extent of occult malignant and premalignant GI lesions has been demonstrated. The future development and evaluation of this technology are discussed.

Citations

Mar 1, 2002·British Journal of Cancer·H ScherüblE-O Riecken
Apr 19, 2003·Journal of Clinical Gastroenterology·Cyrus R Kapadia
Aug 2, 2003·Technology in Cancer Research & Treatment·Louis-Michael Wong Kee Song, Kenneth K Wang
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Haruhiro InoueAkira Shiokawa
Nov 19, 2005·Journal of Biomedical Optics·I MunroP M W French
Jun 20, 2006·Scandinavian Journal of Gastroenterology. Supplement·Jacques J G H M Bergman
Oct 13, 2006·Current Opinion in Gastroenterology·Brian C Jacobson, Jacques Van Dam
Jan 8, 2008·Alimentary Pharmacology & Therapeutics·F J C van den BroekE Dekker
Feb 12, 2011·Expert Review of Gastroenterology & Hepatology·Robert J BasseriKonstantinos A Papadakis
Dec 24, 2011·Gastroenterology Research and Practice·Hiroyuki AiharaTakeshi Suzuki
Mar 29, 2012·Current Gastroenterology Reports·Michelle H LeeSharmila Anandasabapathy
Apr 18, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Tomohiko MoriyamaYoshifumi Hori
Nov 1, 2002·Scandinavian Journal of Gastroenterology. Supplement·J Haringsma
May 10, 2002·Journal of Gastroenterology and Hepatology·Ralph S DacostaNorman E Marcon
Apr 19, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M A KaraB C Wilson
Jan 16, 2007·Inflammatory Bowel Diseases·Takayuki MatsumotoMitsuo Iida
Nov 22, 2005·Journal of Surgical Oncology·E J Kuipers, J Haringsma
Oct 31, 2009·Journal of Gastroenterology·Takuya InoueErvin Tóth
Apr 11, 2013·Gastroenterology Research and Practice·Chen-Shuan Chung, Hsiu-Po Wang
Jan 9, 2015·European Journal of Gastroenterology & Hepatology·Tae-Geun GweonMyung-Gyu Choi
Oct 30, 2016·Journal of Biomedical Optics·Silas J LeavesleyCarole W Boudreaux
Jul 12, 2013·Surgical Innovation·Philipp von BreitenbuchHans J Schlitt
Jul 24, 2008·The American Journal of Gastroenterology·Takahisa MatsudaDaizo Saito
Jan 1, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T MatsumotoM Iida
Apr 4, 2009·Journal of Biophotonics·Annieke NijssenGerwin J Puppels
Apr 28, 2010·International Journal of Colorectal Disease·Ken InoueToshikazu Yoshikawa
Apr 24, 2014·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kenichi GodaHisao Tajiri
Jan 27, 2016·World Journal of Gastroenterology : WJG·Markus BrücknerDominik Bettenworth
Dec 25, 2010·Therapeutic Advances in Gastroenterology·Jelle HaringsmaErnst J Kuipers
Feb 29, 2020·Photodiagnosis and Photodynamic Therapy·Sebastian KwiatekAgata Stanek
Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
Nov 5, 2003·Gastrointestinal Endoscopy·Klaudia NiepsujAleksander Sieroń

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