PMID: 7540603Apr 1, 1995Paper

Autoimmune-associated MHC class II molecules

Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
M Trüeb

Abstract

The major histocompatibility complex (MHC) is a large region of highly polymorphic genes. MHC-encoded molecules bind foreign-protein antigens and form complexes that are recognized by antigen-specific T lymphocytes. Interactions between MHC-peptide complexes and T-cell receptors play a central role in the selection of the T-cell repertoire and in the elicitation of an immune response. The majority of disease associations with the MHC have been with class-II molecules. Despite the awareness of such associations, the pathophysiological role of MHC class-II molecules in conferring susceptibility to autoimmune disease is poorly understood. The recent demonstration that human class-II molecules can function as antigen-presenting molecules in vivo in a transgenic murine system paves the way to investigate the role of HLA class II molecules in regulating immune responses and disease susceptibility. These mice should be useful for studying the mechanisms by which particular human leukocyte antigen (HLA) alleles are associated with specific human-autoimmune diseases.

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Current Pharmaceutical Design
Stephanie L DayVasso Apostolopoulos
Current Molecular Medicine
F Susan Wong, Li Wen
Seminars in Respiratory and Critical Care Medicine
Johan Grunewald
Microbes and Infection
Janko Nikolich-ZugichIlhem Messaoudi
© 2021 Meta ULC. All rights reserved