Autoimmune disease-related primary CNS lymphoma: systematic review and meta-analysis.

Journal of Neuro-oncology
Leon D KaulenJoachim M Baehring

Abstract

Recent studies suggest a relatively high prevalence of autoimmune disorders (AD) among primary CNS lymphoma (PCNSL) patients, however, the literature is limited to case reports. To gain a better understanding of AD-PCNSL we reviewed and analyzed all cases described in the literature. We searched the MEDLINE database using the search terms 'central nervous system lymphoma' or 'CNS lymphoma' along with AD-related terms. We selected 39 records for qualitative synthesis of data and identified 50 AD-PCNSL. Clinical, imaging and outcome data were collected. Overall survival (OS) was analyzed with the Kaplan-Meier method. Univariate and multivariate analyses were performed using log rank test and Cox proportional hazard model. Most common AD were systemic lupus erythematosus (24%), multiple sclerosis (16%), and myasthenia gravis (14%). All patients had received immunosuppressants for their AD. Median interval from AD until PCNSL diagnosis was 108 months (range: 11-420). Male-to-female ratio was 0.42 and AD-PCNSL was diagnosed at a median age of 57 years (range: 2-88). On imaging lesions typically localized to the hemispheres (65%) and displayed peripheral enhancement (74%). Pathological evaluation revealed diffuse large-B-cell lymphom...Continue Reading

References

Jan 7, 2000·The American Journal of Pathology·R F Ambinder
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C ThériaultT Al Saati
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrés J M FerreriFranco Cavalli
Nov 17, 2005·Archives of Internal Medicine·Elias ZintzarasHaralampos M Moutsopoulos
Jan 6, 2007·Nature Clinical Practice. Neurology·Fred H HochbergEphraim P Hochberg
May 25, 2007·Neuro-oncology·Brian Patrick O'NeillCaterina Giannini
May 6, 2008·Blood Reviews·Huy TranMaher K Gandhi
Oct 30, 2008·Journal of Neuropathology and Experimental Neurology·B K Kleinschmidt-DeMastersCaterina Giannini
Jan 7, 2010·Cancer·Robert CavaliereUNKNOWN International Primary Central Nervous System Lymphoma Collaborative Group
Apr 29, 2010·Brain : a Journal of Neurology·Emmanuelle LerayGilles Edan
May 15, 2013·Nature Reviews. Neurology·Agnieszka Korfel, Uwe Schlegel
Jun 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A M EvensR Trappe
Mar 29, 2016·British Journal of Haematology·Meredith S ShielsEric A Engels
Aug 5, 2016·The Indian Journal of Medical Research·Mehar Chand SharmaVinod Raina
Sep 28, 2017·Cancer·Catherine H Han, Tracy T Batchelor
Jul 22, 2018·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Seok-Jin KimWon Seog Kim
Aug 21, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn C ArbourMatthew D Hellmann
Jun 14, 2019·Journal of Neuro-oncology·Leon D KaulenJoachim M Baehring
Oct 19, 2019·British Journal of Haematology·Parag MahaleMeredith S Shiels

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Citations

Jun 3, 2021·Cancers·Philipp KarschniaLouisa von Baumgarten

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