Autoimmune heart failure: new understandings of pathogenesis

The International Journal of Biochemistry & Cell Biology
Urs Eriksson, Josef M Penninger

Abstract

Besides genetic susceptibility and infections with cardiotropic viruses, autoimmune responses against heart tissue play a major role in the pathogenesis of dilated cardiomyopathy, the most common cause of heart failure in young patients. Recent findings suggest that the combination of tissue damage resulting in release of self-antigens, together with non-specific activation of the innate immune system triggers various responses that are crucial for the development of heart-specific autoimmunity. Understanding these mechanisms is critical for the design and development of novel treatment strategies against devastating heart diseases in the future.

References

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Citations

Apr 1, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Udi Nussinovitch, Yehuda Shoenfeld
Jun 1, 2013·Cardiovascular Drugs and Therapy·Kazuko TajiriKazutaka Aonuma
Aug 2, 2006·The Journal of Experimental Medicine·Manu RangachariUrs Eriksson
Feb 8, 2006·Annual Review of Physiology·Viviany R TaquetiAndrew H Lichtman
Nov 20, 2009·International Journal of Cardiology·Yusuke SugiTsutomu Imaizumi
Aug 18, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Charline Wehlou, Joris R Delanghe
Sep 20, 2011·European Journal of Immunology·Zhaoliang SuHuaxi Xu
Aug 8, 2006·International Journal of Cardiology·René R Marty, Urs Eriksson
Jul 25, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Hyelim ParkBoyoung Joung
Nov 8, 2014·Journal of the American Heart Association·Tomoko Machino-OhtsukaKyoko Imanaka-Yoshida
Sep 22, 2010·Circulation·Aranzazu Cruz-AdaliaPilar Martín
Jan 13, 2006·Circulation·René R MartyUrs Eriksson
Oct 2, 2015·Clinical and Experimental Pharmacology & Physiology·Ozge PamukcuKazim Uzum
Jun 12, 2008·Journal of Cardiovascular Medicine·Graziella CastellanoSerafino Fazio
Jul 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuko TajiriYasuhiro Yasutomi
May 24, 2020·Journal of Cardiovascular Translational Research·Elise L KesslerSaskia C A de Jager
Mar 13, 2019·Disease Models & Mechanisms·Chandan SangheraSusanne Sattler

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