PMID: 16510039Mar 3, 2006Paper

Autoimmune hepatitis: diagnosis, treatment, and prognosis

Current Gastroenterology Reports
Bruce A Luxon

Abstract

Autoimmune hepatitis (AIH) is an idiopathic hepatitis of unknown cause characterized by histologic evidence of chronic inflammation, liver autoantibodies, and increased gamma globulins in the serum. The clinical manifestations of AIH have been known since the 1950s and are essentially unchanged over the past 50 years. The cornerstone of therapy for AIH is immunosuppression using prednisone and azathioprine, with the vast majority of patients achieving clinical remission. This review provides a concise summary of the diagnostic criteria for AIH, describes its proposed pathogenic mechanisms and epidemiology, and offers an algorithmic approach to its initial treatment and follow-up.

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Citations

Jun 15, 2010·Italian Journal of Pediatrics·Henedina AntunesSofia Martins
Nov 12, 2010·Italian Journal of Pediatrics·Amel A M ElfaramawyHeba M Abdel Aziz
May 24, 2008·Gastroenterology Clinics of North America·Bruce A Luxon
Dec 6, 2016·International Journal of Molecular Sciences·Urs Christen, Edith Hintermann
Jun 4, 2019·BMJ Case Reports·Hannah Yeend-Curd-TrimbleDouglas MacDonald

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Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

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