Autoimmune hepatitis: East meets west

Journal of Gastroenterology and Hepatology
Fan YangXiong Ma

Abstract

Autoimmune hepatitis (AIH) is an inflammatory liver disease with diverse clinical spectrum, which predominantly affects females. This review provides detailed comparisons of epidemiology, genetic predispositions, clinical features, risk factors of hepatocellular carcinoma, and mortality in AIH patients between eastern and western countries. AIH prevalence and incidence are lower in Asia-Pacific area than in Europe and America. European and American patients seem to have more severe disease, characterized with human leukocyte antigen-DR3 haplotype, younger age, more AIH-induced "cirrhosis" at diagnosis, higher elevated serum immunoglobulin G levels, and positive rate of antisoluble liver antigen/liver pancreatitis. The overall AIH diagnostic accuracy of revised original criteria and simplified scoring system are similar in European/American populations and Asian. Cirrhosis at presentation and non-response to immunosuppressive therapy within 1 year are the most important predictors for poor prognosis of AIH patients.

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Citations

Nov 29, 2015·Journal of Autoimmunity·Qixia WangXiong Ma
Sep 26, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki NishikawaShuhei Nishiguchi
Mar 16, 2017·Clinical and Molecular Hepatology·Angela Cropley, Martin Weltman
Apr 28, 2017·Journal of Digestive Diseases·UNKNOWN Chinese Society of Hepatology, Chinese Society of Gastroenterology & Chinese Society of Infectious Diseases
May 18, 2019·Journal of Digestive Diseases·Rui Ling ChenXiong Ma
Jul 1, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Hsu-Kai HuangYin-Chou Hsu
Oct 23, 2019·Molecular Medicine Reports·Han WangWei Yan
Sep 29, 2020·Journal of Translational Internal Medicine·Abbas Ali Tasneem, Nasir Hassan Luck
Mar 27, 2018·Journal of Clinical and Translational Hepatology·Qi-Xia WangXiong Ma
Mar 31, 2021·Internal and Emergency Medicine·Koji FujitaTsutomu Masaki
Sep 4, 2021·Transplantation Proceedings·Khalid AlswatWaleed K Al-Hamoudi

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