Autoimmune Hepatitis Overlap Syndromes and Liver Pathology

Gastroenterology Clinics of North America
Albert J Czaja, Herschel A Carpenter

Abstract

Autoimmune hepatitis (AIH) may have an atypical serum alkaline phosphatase elevation, antimitochondrial antibodies, histologic features of bile duct injury/loss, or cholangiographic findings of focal biliary strictures and dilations. These manifestations characterize the overlap syndromes. Patients can be classified as having AIH with features of primary biliary cholangitis, primary sclerosing cholangitis, or a cholestatic syndrome. The gold standard of diagnosis is clinical judgment. Histologic evaluation is a major diagnostic component. Treatment is based on algorithms; outcomes vary depending on the predominant disease component. Combination therapy has been the principal recommendation.

Citations

Aug 14, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shuichiro UmetsuTomoo Fujisawa
Dec 22, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cara L MackAlbert J Czaja
May 18, 2020·Journal of Clinical Medicine·Benjamin L FreedmanAlan Bonder
Sep 30, 2021·Clinical Reviews in Allergy & Immunology·Francesca ColapietroElena Generali

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