Abstract
Since the discovery of an almost 100% association of HLA-DR2 with narcolepsy-cataplexy, many efforts have been made to demonstrate the intervention of immune factors in the pathogeny of the disease. Some epidemiological features could support this hypothesis: age of onset around 25, triggering factors, association with multiple sclerosis. Molecular studies at the DNA level have, up to now, failed to uncover an abnormal gene in the HLA system, which would imply that the DR2 antigen acts through its role in the immune response. However, results have been largely inconclusive as far as classical features of autoimmunity in blood and CSF are concerned. In canine narcolepsy, a linkage with a human immunoglobulin-related gene has recently been shown, and may constitute a counterpart of the HLA association in man. Thus, the hypothesis of a transient and discrete autoimmune aggression may be ruled out.
References
Mar 1, 1991·Neurology·D S YoungerM J Thorpy
Mar 1, 1990·Human Immunology·D H SilvermanM L Karnovsky
Aug 1, 1989·Annals of Neurology·D B Drachman, R W Kuncl
Jan 1, 1986·Immunogenetics·H InokoY Honda
Jan 1, 1988·Immunogenetics·C B LockJ Trowsdale
Jan 1, 1985·Folia Psychiatrica Et Neurologica Japonica·K MatsukiT Juji
Oct 1, 1966·Archives of Neurology·K Ekbom
Nov 1, 1984·Tissue Antigens·T JujiY Doi
Jan 1, 1963·Acta Neurologica Scandinavica·O Berg, J Hanley
Citations
Jun 1, 1995·Seizure : the Journal of the British Epilepsy Association·T MoenA Holst
Mar 25, 2000·Sleep Medicine·S C HongE Mignot
Apr 1, 1997·Tissue Antigens·E MignotP Underhill
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christian SieboldLars Fugger
Jun 30, 2001·Journal of Neuroimmunology·L LinE Mignot
Jan 2, 2016·Progress in Neurobiology·Sarah Wurts BlackThomas S Kilduff
May 16, 2014·Immunologic Research·Emmanuel J M Mignot
May 7, 2013·Sleep Medicine·Maurice M Ohayon
Jun 4, 2010·Environmental Research·Thanh G N TonThomas D Koepsell
Feb 17, 2001·American Journal of Human Genetics·E MignotN Risch
Jun 1, 1997·American Journal of Human Genetics·E Mignot
Apr 25, 2000·Genomics·J NakayamaT Arinami
Sep 6, 2000·Nature Medicine·C PeyronE Mignot
Aug 9, 2006·Expert Review of Neurotherapeutics·Martin B Scharf
Dec 13, 2019·Biologie aujourd'hui·Jean-Marie Ravel, Emmanuel J M Mignot
May 20, 1998·Genome Research·H KadotaniE Mignot
Jul 21, 2001·Annals of the New York Academy of Sciences·T E Brown, W J McMullen