Autoimmune-induced damage of the midbrain dopaminergic system in lupus-prone mice

Journal of Neuroimmunology
David A BallokB Sakic

Abstract

Spontaneous development of lupus-like disease is accompanied by impaired dopamine catabolism and degenerating axon terminals in the mesencephalon of MRL-lpr mice. We presently examine the hypothesis that systemic autoimmunity affects the central dopaminergic system in behaviorally impaired animals. The functional damage of the nigrostriatal pathway was assessed from rotational behavior after a single injection of the D1/D2-receptor agonist apomorphine. Neurodegeneration in the midbrain was estimated by Fluoro Jade B (FJB) staining. The causal role of autoimmunity was tested by comparing asymptomatic and diseased MRL-lpr mice, and by employing the immunosuppressive drug cyclophosphamide. Damage of dopaminergic neurons was assessed by tyrosine-hydroxylase (TH) staining of the midbrain. Apomorphine induced significant asymmetry in limb use, which lead to increased circling in the diseased MRL-lpr group. While FJB-positive somas were not seen in the striatum, increased staining in the substantia nigra (SN) and ventral tegmental area (VTA) were detected in behaviorally impaired MRL-lpr mice, but not in age-matched controls. Reduced brain mass and increased levels of TNF-alpha in their cerebrospinal fluid (CSF) suggested cerebral atr...Continue Reading

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Citations

Jun 15, 2006·Cellular and Molecular Neurobiology·Kamila SaganováIvo Vanický
Apr 5, 2013·Clinical & Experimental Neuroimmunology·Katarina MarcinkoBoris Sakic
Feb 19, 2011·Journal of Biomedicine & Biotechnology·Maria Gulinello, Chaim Putterman
Apr 13, 2013·Cellular and Molecular Life Sciences : CMLS·Elizabeth BrintAileen Houston
Sep 4, 2014·Autoimmunity Reviews·Hélène Jeltsch-David, Sylviane Muller
Jul 17, 2012·Behavioural Brain Research·Minesh KapadiaBoris Sakic
Sep 6, 2011·Progress in Neurobiology·Minesh Kapadia, Boris Sakic
Oct 27, 2009·Brain, Behavior, and Immunity·Mile StanojcicBoris Sakic
Jan 16, 2007·Brain Research Reviews·David A Ballok
Aug 28, 2007·The Journal of Comparative Neurology·Gilmor I KeshetHelen M Blau
Oct 4, 2005·Journal of Neuroimmunology·Boris SakicLaurie C Doering
Aug 6, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Jiali ZhuZhenghong Qin
Aug 25, 2012·Journal of Neuroimmunology·Sebastian StielkeChristian Mawrin
Apr 9, 2014·Frontiers in Immunology·Rodrigo PachecoMoncef Zouali
Apr 11, 2017·Lupus·R PikmanS G Gofrit
Apr 13, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Minesh KapadiaBoris Sakic
Feb 18, 2011·The Journal of Rheumatology·Noura HassanSasha Bernatsky
Aug 24, 2006·The Journal of Comparative Neurology·Kasey L BakerJoanne C Conover
Jan 29, 2017·Immunologic Research·Luis J JaraLuis R Espinoza

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