PMID: 11345201May 10, 2001Paper

Autoimmune neutropenia with cyclic oscillation of neutrophil count after steroid administration

International Journal of Hematology
N HiraseJ Nishimura

Abstract

A 16-year-old female patient was evaluated for pancytopenia. She had a white blood cell count of 1.6 x 10(9)/L with 0.02 neutrophils and a platelet count of 19 x 10(9)/L. In the bone marrow, mature granulocytes were markedly decreased in number, but no atypical cells were present. Antineutrophil antibody was demonstrated by flow cytometry, and the level of platelet-associated immunoglobulin G was increased. A diagnosis of autoimmune neutropenia and thrombocytopenia was made. Interestingly, neutrophil and platelet counts fluctuated cyclically after the initiation of prednisolone therapy. The neutrophil count fluctuated between 0.1 x 10(9)/L and 7 x 10(9)/L, and the platelet count fluctuated between 19 x 10(9)/L and 175 x 10(9)/L, in 4-week cycles. Following splenectomy, neutrophil and platelet counts normalized. We believe the immune mechanism of recurrent neutropenia in this patient differs from that in other patients with cyclic neutropenia reported with stem cell disorders.

References

Oct 9, 1975·The New England Journal of Medicine·P LalezariM Santorineou
Oct 9, 1975·The New England Journal of Medicine·L A BoxerT P Stossel
Nov 1, 1991·Annals of Hematology·J BuxC Mueller-Eckhardt
Feb 1, 1991·The American Journal of Medicine·G L LogueJ L Iglehart
Sep 1, 1988·Blood Reviews·D C Dale, W P Hammond
Nov 1, 1986·The Journal of Pediatrics·P LalezariM Petrosova

❮ Previous
Next ❯

Citations

Feb 7, 2002·Pharmacoepidemiology and Drug Safety
Feb 7, 2018·Transfusion·Tomohiro YabushitaTakayuki Ishikawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
A ElhendyA H Balk
© 2021 Meta ULC. All rights reserved