Autoimmune pancreatitis-related diabetes: quantitative analysis of endocrine islet cells and inflammatory infiltrate.

Virchows Archiv : an International Journal of Pathology
Alton B FarrisVikram Deshpande

Abstract

In autoimmune pancreatitis (AIP), mechanism(s) of paradoxical glycemic control improvement (GCI) often occurring after pancreatic resection and steroid therapy are not fully elucidated. Using image quantitation, AIP cases (n = 10) with pre- and post-surgical glucose values were compared with chronic pancreatitis (CP) and normal pancreas (NP) regarding percent chromogranin immunohistochemistry (IHC) positivity as a surrogate marker of endocrine endowment; intra-islet T and B lymphocyte and plasma cell enumeration with CD3, CD20, and IgG4 IHC; and CD34 IHC islet vascularity quantitation. Postsurgical GCI, noted in 8/10 (80%) AIP cases, approached statistical significance (P = 0.07) compared to CP. Endocrine endowment reduction, noted by a lower percent of chromogranin + pancreatic parenchyma, was seen in AIP (4.54%) and CP (3.20%) compared to NP (7.95%); only the CP decrease was statistically significant (P = 0.02) since AIP often had ductular endocrine neogenesis. Regression suggested an inverse correlation between endocrine endowment and GCI in AIP (R = 0.62, P = 0.06). AIP islets were smaller and disrupted by inflammatory cell infiltration. Compared to CP, AIP islets had higher CD3 + and CD20 + cell densities. IgG4 + plasma ce...Continue Reading

References

May 1, 1983·Diabetologia·J RahierJ C Henquin
Apr 20, 2000·The Journal of Clinical Investigation·K B HahmS J Kim
Mar 10, 2001·The New England Journal of Medicine·H HamanoK Kiyosawa
Jul 9, 2002·Clinical and Experimental Immunology·W-M QuM Nose
Jul 29, 2003·The American Journal of Surgical Pathology·Kenji NotoharaThomas C Smyrk
Jul 1, 1961·The American Journal of Digestive Diseases·H SARLESC GUIEN
Oct 20, 2004·Journal of Clinical Gastroenterology·Ioannis G KetikoglouAntonios M Moulakakis
Nov 2, 2004·Virchows Archiv : an International Journal of Pathology·Giuseppe ZamboniGünter Klöppel
Mar 4, 2005·The American Journal of Pathology·Todd S DavidsonWilliam F Hickey
Mar 19, 2005·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mari Mino-Kenudson, Gregory Y Lauwers
Apr 28, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Terumi KamisawaAtsutake Okamoto
Aug 27, 2005·Archives of Pathology & Laboratory Medicine·Vikram DeshpandeGregory Y Lauwers
Oct 15, 2005·The American Journal of Surgical Pathology·Vikram DeshpandeGregory Y Lauwers
Aug 4, 2006·Gastroentérologie Clinique Et Biologique·Ivan GraberJérôme Dumortier
Sep 19, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lizhi ZhangThomas C Smyrk
Nov 24, 2006·The American Journal of Surgical Pathology·Vikram DeshpandeGregory Y Lauwers
Apr 7, 2007·The American Journal of Surgical Pathology·Motohiro KojimaGünter Klöppel
May 24, 2007·Journal of Gastroenterology·Günter KlöppelToshio Morohoshi
Jul 10, 2007·The Journal of Clinical Endocrinology and Metabolism·George S Eisenbarth
Aug 19, 2007·The British Journal of Surgery·D P ToomeyK C Conlon
Sep 27, 2007·The American Journal of Surgical Pathology·Lynn D CornellRobert B Colvin
Nov 6, 2007·Trends in Immunology·Daniel S Straus, Christopher K Glass
Jan 16, 2008·Journal of Cellular and Molecular Medicine·R A TownerF Lupu
Nov 28, 2008·Diabetologia·B A MengeJ J Meier

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Citations

Oct 17, 2012·Seminars in Diagnostic Pathology·Shweta ShinagareVikram Deshpande
Jun 1, 2011·Surgical Pathology Clinics·Alton B FarrisN Volkan Adsay
Feb 11, 2015·Medicina clínica·Suset Dueñas DisotuarMaría Asunción Martínez-Brocca
Nov 9, 2017·Virchows Archiv : an International Journal of Pathology·Andres MoonAlton B Brad Farris
Feb 6, 2017·Archives of Pathology & Laboratory Medicine·Alton Brad FarrisGeoffrey H Smith
May 5, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Ken TakeshimaTakashi Akamizu
Aug 2, 2018·World Journal of Gastroenterology : WJG·Franz-Tassilo Müller-GraffDietmar Zechner

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