Autoimmune paraneoplastic cerebellar degeneration: immunohistological localization of antibody-binding sites

Clinical Neurology and Neurosurgery
E NardelliF Graus

Abstract

Sera from 3 patients with breast or ovarian tumors and paraneoplastic cerebellar degeneration (PCD) contained anti-Purkinje cell antibodies (PCAbs) which also bind to other neurons on frozen sections of adult rodent brain. PCAbs tested on new-born rodent (rabbit, rat, mouse) brain tissue detected only oligodendrocyte-like cells (ODLC) in the white matter and allowed us to speculate on the nature of the antigenic structure in the neuronal cytoplasm. All these PCAbs appear histochemically identical and recognize antigens which belong to so-called "Yo" proteins.

References

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Citations

Nov 13, 2007·Neuropathology and Applied Neurobiology·F Aboul-EneinW Kristoferitsch

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