Autoimmune peripheral neuropathies

Clinica Chimica Acta; International Journal of Clinical Chemistry
Pierre R BourqueRami Massie

Abstract

Peripheral nervous system axons and myelin have unique potential protein, proteolipid, and ganglioside antigenic determinants. Despite the existence of a blood-nerve barrier, both humoral and cellular immunity can be directed against peripheral axons and myelin. Molecular mimicry may be triggered at the systemic level, as was best demonstrated in the case of bacterial oligosaccharides. The classification of immune neuropathy has been expanded to take into account specific syndromes that share unique clinical, electrophysiological, prognostic and serological features. Guillain-Barré syndrome encompasses a classical syndrome of acute demyelinating polyradiculoneuropathy and many variants: axonal motor and sensory, axonal motor, Miller-Fisher, autonomic, and sensory. Similarly, chronic immune neuropathy is composed of classic chronic inflammatory demyelinating polyradiculoneuropathy and variants characterized as multifocal (motor or sensorimotor), sensory, distal symmetric, and syndromes associated with monoclonal gammopathy. Among putative biomarkers, myelin associated glycoprotein and several anti-ganglioside autoantibodies have shown statistically significant associations with specific neuropathic syndromes. Currently, the stro...Continue Reading

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Citations

Mar 6, 2016·Pain·Siddarth ThakurDavid N Herrmann
Oct 3, 2017·Continuum : Lifelong Learning in Neurology·James A Russell
Sep 29, 2020·Journal of Neuromuscular Diseases·Josef FinstererStefan Iglseder
Jul 26, 2017·Neurocritical Care·T CernyE Keller
May 19, 2019·International Journal of Environmental Research and Public Health·Hilary L ColbethDavid J Prezant
Mar 23, 2021·The Journal of Experimental Medicine·Masha G Savelieff, Eva L Feldman

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