PMID: 3756819Nov 1, 1986Paper

Autoimmune phenomena and cytogenetic findings in a patient with carcinoma (seminoma) in situ

Cancer
D LehmannH Müller

Abstract

Routine examination of a testis biopsy from a patient with oligospermia and a large varicocele in his left testicle and who was childless for over 2 years showed carcinoma in situ (CIS) with atypic spermatogonia in his right testicle. Immunohistochemical investigations of this tissue revealed large intracellular deposits of immunoglobulin G (IgG) restricted to the atypical cells. By blot-immunobinding test of the patient's serum, circulating antibodies against a molecule with an approximate molecular weight of 60 kD were found. Such antibodies were not found in a total of over 500 infertile patients and fertile controls examined. This molecule was extracted from pooled normal human sperms by trypsin digestion and eluted out of a sodium dodecyl-sulphate polyacrylamide gel (SDS-PAGE). This elute is currently used for raising monoclonal antibodies. An analysis of the direct chromosome preparations from the testis biopsy showed both numerical and structural chromosomal aberrations. This might indicate that the atypical cells have already been transformed and hence could be considered as malignant.

References

Apr 13, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M E Bramwell, H Harris
Dec 1, 1985·Journal of Reproductive Immunology·D LehmannH Müller
Aug 1, 1985·Cancer Genetics and Cytogenetics·N B Atkin, M C Baker
Sep 9, 1972·Lancet·N E Skakkebaek
Oct 1, 1983·Cancer Genetics and Cytogenetics·N B Atkin, M C Baker
Jun 15, 1984·Science·G F Springer
Mar 1, 1949·The Journal of Urology·A PALOMO
Mar 1, 1981·International Journal of Andrology·Chr Sigg, Chr Hedinger

❮ Previous
Next ❯

Citations

Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Horwich
Feb 1, 1989·American Journal of Reproductive Immunology : AJRI·D Lehmann, L R Emmons
Sep 2, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jian Jun GaoDouglas G McNeel
Feb 1, 1987·International Journal of Andrology·D Lehmann, H Müller
Aug 1, 1989·The Journal of Urology·Y ReinbergE E Fraley
Jan 6, 2001·Scandinavian Journal of Urology and Nephrology. Supplementum·M RørthN E Skakkebaek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.