PMID: 8983326Sep 1, 1996Paper

Autoimmune polyglandular syndrome and primary biliary cirrhosis

The British Journal of Clinical Practice
G T KoC S Cockram

Abstract

Liver involvement in autoimmune polyglandular syndrome (APS) in the form of chronic active hepatitis has been well described. However, to our knowledge, primary biliary cirrhosis in APS has not been reported. Here we report the case of a 27-year-old man who presented with classical insulin-dependent diabetes mellitus and subsequently developed Hashimoto's thyroiditis, hypogonadism, and primary biliary cirrhosis. The latter diagnosis was confirmed by a cholestatic pattern of liver enzymes, positive anti-mitochondrial antibody, normal cholangiogram, and characteristic liver biopsy findings. Primary biliary cirrhosis should probably be regarded as a possible, though uncommon, component of APS.

Related Concepts

Related Feeds

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Related Papers

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
M R Borgaonkar, D G Morgan
Journal of Clinical Gastroenterology
K M HoltM Chojkier
Digestive Diseases and Sciences
Pilar Sánchez-PobreJa Solís-Herruzo
© 2022 Meta ULC. All rights reserved