PMID: 8591112Feb 1, 1995Paper

Autoimmune premature ovarian failure

The Journal of Obstetrics and Gynaecology
J G KimJ Y Lee

Abstract

Premature ovarian failure (POF) may be caused by a variety of factors that result in the depletion of responsive ovarian follicles. There is a increasing body of evidence that suggests an autoimmune etiology in some POF patients. Data in support of an autoimmune etiology include: (1) lymphocytic and plasma cell infiltration of the ovary and alteration of T cell subsets; (2) circulating autoantibodies to ovarian antigens; (3) association with other "autoimmune" disorders; (4) recovery of ovarian function after regression of autoimmune status. The mechanism for ovarian autoimmunity is unknown. Genetic or environmental factor might be involved in the stimuli inducing immune response. The possibility that major histocompatibility complex antigen and cytokines are implicated in human autoimmune POF has been proposed. The relative contribution of cell-mediated immunity and antibody-mediated immunity remains obscure in animal models and in POF patients. Currently, in vitro fertilization and/or gamete intrafallopian transfer with donated oocytes are the best therapeutic options to achieve pregnancy although ovulation induction and immunosuppressive treatment might be used in approved experimental protocols. A newly developed double bri...Continue Reading

Citations

Jul 11, 1998·Fertility and Sterility·J N Anasti
Apr 30, 2002·Obstetrics and Gynecology·Nahrain H AlzubaidiLawrence M Nelson
Dec 26, 2012·Animal Reproduction Science·Dong LiGuoyun Wang
Dec 9, 2009·Fertility and Sterility·Frederico José Silva CorrêaMauricio Simões Abrão
Jan 1, 2008·Fertility and Sterility·Yuval GielchinskyNeri Laufer
Oct 17, 2003·Endocrinology and Metabolism Clinics of North America·Lawrence M Nelson, Vladimir K Bakalov
Apr 4, 1998·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·N DoldiA Ferrari
Jul 26, 2019·The Journal of International Medical Research·Liming CaoZhishan Zhu
Aug 24, 2019·Journal of Assisted Reproduction and Genetics·Michal Kirshenbaum, Raoul Orvieto

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