Autoimmune prostatitis: evidence of T cell reactivity with normal prostatic proteins

Urology
R B AlexanderS Ponniah

Abstract

To determine whether men with chronic prostatitis/chronic pelvic pain syndrome have evidence of an autoimmune response to prostatic proteins. We examined men with a history of chronic prostatitis/ chronic pelvic pain syndrome for evidence of T lymphocyte reactivity to seminal plasma. Patients underwent automated leukopheresis to obtain peripheral blood mononuclear cells. We performed a recall antigen proliferation assay to detect specific proliferation of peripheral helper T lymphocytes in men. with chronic prostatitis/chronic pelvic pain syndrome and compared the results with those of normal men. The antigen for these studies consisted of seminal plasma from normal donors and men with seminal vesicle atresia. A specific recall proliferative response to seminal plasma was observed in 3 of 10 men with a history of chronic prostatitis/chronic pelvic pain syndrome compared with none of 15 normal men. The CD4 T cell proliferative response to seminal plasma was statistically significant when compared with medium alone in men with a history of chronic prostatitis/chronic pelvic pain syndrome but it was not statistically significant in normal men. The recall responses of both the chronic prostatitis/chronic pelvic pain syndrome group ...Continue Reading

References

Jan 1, 1988·Urologia Internationalis·W WeidnerH Krauss
Apr 1, 1993·Urology·J J de la RosetteF M Debruyne
Oct 1, 1996·Urology·R B Alexander, D Trissel
Mar 1, 1997·The Journal of Urology·R E BergerS L Hillier

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Citations

Jun 27, 2002·Current Urology Reports·R O Roberts, S J Jacobsen
Aug 1, 2002·Current Urology Reports·Robert M Moldwin
Jul 29, 2003·Current Urology Reports·Caroline Maake, Hubert John
Sep 4, 2008·Current Urology Reports·Rajiv SainiAlexis E Te
Jul 3, 2009·Current Urology Reports·Raymond M Bernal, Michel A Pontari
Sep 16, 1999·Journal of Biotechnology·K A BerlynR W Malone
Jan 3, 2007·Prostate Cancer and Prostatic Diseases·E V VykhovanetsS Gupta
Jun 4, 2002·Clinical and Experimental Immunology·G R D BatstoneJ S H Gaston
Oct 31, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·I OrhanA Ardiçoglu
Oct 27, 2001·Journal of General Internal Medicine·M McNaughton CollinsUNKNOWN Chronic Prostatitis Collaborative Research Network
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M MercaderE D Kwon
Jul 21, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marsha L QuickPraveen Thumbikat
Feb 6, 2009·Drugs·Adam B MurphyRobert B Nadler
Jan 1, 2008·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Ram Vaidyanathan, Vibhash C Mishra
Jun 28, 2005·Current Urology Reports·Regula Doggweiler Wiygul
Nov 24, 2004·Clinical Evidence·Anthony Schaeffer, Jeffrey Stern
Jun 4, 2008·Current Urology Reports·Michel A Pontari
Feb 11, 2004·Journal of Immunotherapy·Elena N KlyushnenkovaRichard B Alexander
May 19, 2010·Expert Review of Clinical Immunology·Giuseppe PennaLuciano Adorini
Sep 22, 2009·The Journal of Urology·Diana V KouiavskaiaRichard B Alexander
Apr 25, 2008·The Journal of Urology·Michel A Pontari, Michael R Ruggieri
Jan 1, 2008·International Journal of Antimicrobial Agents·A J Schaeffer
Feb 20, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Douglas G McNeel
Apr 25, 2007·The Prostate·Elena N KlyushnenkovaRichard B Alexander
Jul 20, 2007·Scandinavian Journal of Immunology·R D MotrichV E Rivero
Jun 11, 2009·International Journal of Andrology·B FibbiM Maggi
Aug 18, 2004·The Journal of Urology·Michel A Pontari, Michael R Ruggieri
Dec 9, 2004·Immunology Letters·Douglas G McNeel, Miroslav Malkovsky
May 6, 2004·The Journal of Urology·Richard B AlexanderMarcie Kincaid

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