PMID: 6983963Jan 1, 1982Paper

Autoimmune reactions and rheumatoid arthritis

European Journal of Rheumatology and Inflammation
K Fehr

Abstract

The reviewed data suggest with a high degree of certainty that IgG and IgG antibodies in immune complexes as well as native and denatured collagen type I, II, and III are autoantigens capable of inducing T cell activation in patients with RA. Proteoglycans and their derivatives seem to modify lymphocyte reactions in a largely non-specific way and their potential to activate T Lymphocytes in RA has still to be confirmed. The occurrence of activation products of T lymphocytes in synovial tissue incubates and synovial fluid of RA patients that is of lymphokines seems to be established. The major autoantibody synthesized by synovial tissue (ST) of seropositive and seronegative RA and juvenile RA patients is IgG- rheumatoid factor (RF) and in seropositive adult cases in addition IgM-Rf. Synthesis of various types of agglutinators by ST plasma cells of adult and juvenile RA patients is a distinct but less prominent feature--than synthesis of Rf. In addition indirect evidence suggests that RA-ST synthesizes to some degree antibodies directed against native and denatured collagen type I/II/III and antibodies directed against different nuclear antigens as well as immunoconglutinin. All these autoantibodies seem to participate in the imm...Continue Reading

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.