Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis

Arthritis Research & Therapy
Uta HardtCaroline Grönwall

Abstract

Immunoglobulin M (IgM) autoreactivity to malondialdehyde (MDA) protein modifications is part of the natural antibody repertoire in health and may have beneficial functions. In contrast, IgG anti-MDA are increased in chronic inflammation and autoimmunity and may instead have pathogenic properties. Herein, we investigated serum IgG anti-MDA levels by enzyme-linked immunosorbent assay (ELISA) in 398 systemic lupus erythematosus (SLE) patients in the Swedish Karolinska SLE cohort and compared these to findings in 225 US SLE patients from New York University and Johns Hopkins University. In two independent cohorts, IgG anti-MDA levels correlated positively with disease activity by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; p < 0.0001, Spearman R = 0.3). Meta-analysis found an odds ratio of 2.7 (confidence interval (CI) 1.9-3.9; p < 0.0001) for high anti-MDA IgG levels with active disease (SLEDAI ≥ 6). Furthermore, IgG anti-MDA correlated directly with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), soluble tumor necrosis factor receptors (sTNFR-1, sTNFR-2), and vascular cell adhesion molecule 1 (VCAM-1) measurements, and inversely with complement factors (C1q, C2, C3, C4). Importantly, IgG anti-...Continue Reading

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Citations

Jul 10, 2019·PloS One·Daniela FrascaBonnie B Blomberg
Jun 3, 2020·Immunological Reviews·Daniela FrascaLaura Haynes
Jul 23, 2020·International Journal of Rheumatology·Nur AtikLaniyati Hamijoyo
Jul 3, 2021·Journal of Clinical Medicine·Simona Roxana GeorgescuMircea Tampa

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Methods Mentioned

BETA
MDA
anti-MDA
enzyme-linked immunosorbent assay
ELISA
ESR

Software Mentioned

Review Manager
Prism
R
JMP
GraphPad
SELENA

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