Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Martti LaanPärt Peterson

Abstract

Autoimmune regulator (Aire) has been viewed as a central player in the induction of tolerance. This study examines whether Aire can modulate the production of the thymic chemokines involved in corticomedullary migration and thus play a role in intrathymic thymocyte migration and maturation. Aire deficiency resulted in reduced gene expression and protein levels of the CCR4 and CCR7 ligands in whole thymi of mice, as determined by quantitative PCR analysis and ELISA. The expression of the CCR4 ligands coincided with Aire expression in the CD80(high) medullary thymic epithelial cells, whereas the expression of the CCR7 ligands was detected in other cell populations. Also, the expression pattern of the CCR4 and CCR7 ligands follows that of Aire during postnatal but not during embryonic development. In vitro, overexpression of Aire resulted in an up-regulation of selected CCR4 and CCR7 ligands, which induced selective migration of double-positive and single-positive CD4(+) cells. In vivo, Aire deficiency resulted in a diminished emigration of mature CD4(+) T cells from the thymi of 5-day-old mice. In conclusion, Aire regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated mat...Continue Reading

References

Jun 1, 1992·The Journal of Experimental Medicine·T MizuochiK Hirokawa
Dec 17, 1997·Nature Genetics·K NagamineN Shimizu
Apr 20, 1999·Biochemical and Biophysical Research Communications·M HeinoK Krohn
Aug 11, 2004·The Journal of Experimental Medicine·Tomoo UenoYousuke Takahama
Aug 11, 2004·The Journal of Experimental Medicine·Ana MisslitzReinhold Förster
Jan 18, 2005·Nature Reviews. Molecular Cell Biology·Erik J Sontheimer
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Noriyuki KurodaMitsuru Matsumoto
Jun 29, 2005·The Journal of Experimental Medicine·Jens DerbinskiBruno Kyewski
Aug 23, 2005·Immunity·Mark S AndersonDiane Mathis
Feb 2, 2006·Immunological Reviews·Alena M Gallegos, Michael J Bevan
Apr 22, 2006·The Journal of Clinical Investigation·Shino NikiMitsuru Matsumoto
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geoffrey O Gillard, Andrew G Farr
May 11, 2006·The Journal of Clinical Endocrinology and Metabolism·Jaakko Perheentupa
Feb 17, 2007·European Journal of Immunology·Ana C M Davalos-MisslitzReinhold Förster
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geoffrey O GillardAndrew G Farr
Jun 30, 2007·Molecular Immunology·Vivian KontPärt Peterson
Nov 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Juan LiWei-Feng Chen
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·François-Xavier HubertHamish S Scott
Aug 9, 2008·Science·James M GardnerMark S Anderson
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·James DooleyAndrew G Farr
Sep 2, 2009·Immunology and Cell Biology·Zivana MilićevićJürgen Westermann

❮ Previous
Next ❯

Citations

Oct 9, 2013·Immunology and Cell Biology·Rong JinQing Ge
Sep 29, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Biju ParekkadanShannon J Turley
Jul 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Céline PomiéJoost P M van Meerwijk
Jun 24, 2010·Genome Biology·Rossella De CegliGilda Cobellis
Jun 5, 2012·Cold Spring Harbor Perspectives in Biology·Yan Xing, Kristin A Hogquist
Feb 2, 2013·Cancer Research·Meng-Lei ZhuMaureen A Su
Jan 31, 2016·Cellular and Molecular Life Sciences : CMLS·Takeshi Nitta, Harumi Suzuki
Mar 15, 2016·Nature Reviews. Immunology·Mark S Anderson, Maureen A Su
Nov 5, 2013·Clinical & Developmental Immunology·Xi XuQing Ge
Jul 15, 2015·Nature Genetics·Ryan P HobbsPierre A Coulombe
Apr 27, 2010·Cell Adhesion & Migration·Jacy GameiroLiana Verinaud
Sep 3, 2011·Blood·Yousuke Takahama
Feb 9, 2017·Frontiers in Immunology·Yirajen Vuddamalay, Joost P M van Meerwijk
Jan 22, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Uku HaljasorgPärt Peterson
Dec 30, 2017·European Journal of Immunology·Jennifer E CowanGraham Anderson
Sep 6, 2017·Immunology·Geraldo A PassosDaniella A Mendes-da-Cruz
May 2, 2013·Science China. Life Sciences·Yaoyao Shi, Mingzhao Zhu
Dec 8, 2010·Immunology and Cell Biology·Mark D BuntingShaun R McColl
Sep 6, 2015·Médecine sciences : M/S·Noëlla LopesMagali Irla
Nov 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuhiro MouriMitsuru Matsumoto
Apr 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katarzyna M SitnikWilliam W Agace
Jul 20, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gabriel SkogbergOlov Ekwall
Apr 16, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Enkhsaikhan LkhagvasurenYousuke Takahama
Apr 30, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Novica M MilićevićŽivana Milićević
Jul 6, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer E CowanGraham Anderson
Nov 12, 2013·European Journal of Immunology·Nuno L AlvesWilliam E Jenkinson
Sep 15, 2015·European Journal of Immunology·Uku HaljasorgPärt Peterson
Feb 28, 2018·Frontiers in Immunology·Roberto Perniola
Apr 19, 2016·Immunological Reviews·Beth LucasGraham Anderson
Jul 23, 2021·Cell Death and Differentiation·Alexia Borelli, Magali Irla
Dec 22, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hitoshi NishijimaMitsuru Matsumoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.