PMID: 7515411May 1, 1994Paper

Autoimmune T cell repertoire in optic neuritis and multiple sclerosis: T cells recognising multiple myelin proteins are accumulated in cerebrospinal fluid

Journal of Neurology, Neurosurgery, and Psychiatry
M SöderströmW X Huang

Abstract

Monosymptomatic unilateral optic neuritis is a common first manifestation of multiple sclerosis. Abnormal T cell responses to myelin components including myelin basic protein (MBP), proteolipid protein (PLP), and myelin-associated glycoprotein (MAG) have been implicated in the pathogenesis of multiple sclerosis. Antigen-reactive T helper type 1 (Th1)-like cells that responded by interferon gamma (IFN-gamma) secretion on antigen stimulation in vitro were counted. Untreated patients with optic neuritis and multiple sclerosis had similarly raised levels of T cells recognising MBP, PLP, and MAG in peripheral blood. Such T cells were strongly enriched in CSF. None of these myelin antigens functioned as immunodominant T cell antigen characteristic for optic neuritis or multiple sclerosis. The autoimmune T cell repertoire was not more restricted in optic neuritis (as an example of early multiple sclerosis). The autoreactive T cell repertoires differed in blood compared with CSF in individual patients with optic neuritis and multiple sclerosis. No relations were found between specificity or quantity of autoreactive T cells in blood or CSF, and clinical variables of optic neuritis or multiple sclerosis, or occurrence of oligoclonal IgG ...Continue Reading

References

Jan 1, 1991·Critical Reviews in Clinical Laboratory Sciences·P D Mehta
Apr 1, 1986·Journal of Neuroimmunology·D R Hampson, S E Poduslo
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P T MassaA Fontana
May 4, 1983·Biochimica Et Biophysica Acta·R H QuarlesL J McIntyre

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Citations

Feb 15, 2001·Journal of Neuroscience Research·N HellingsP Stinissen
Apr 30, 2011·Eye·D PauA G Lee
Dec 7, 2013·Multiple Sclerosis International·Judith M Greer
Mar 3, 2009·Journal of Autoimmunity·Anne Lise Karlsgot HestvikTrygve Holmøy
May 27, 2008·Journal of Autoimmunity·Judith M Greer, Michael P Pender
Feb 13, 2003·Brain Pathology·Mikhail PashenkovHans Link
Apr 9, 2020·Frontiers in Immunology·Yifan ZhouWei Qiu
Nov 24, 2020·Frontiers in Neurology·Yael Redler, Michael Levy

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