Oct 20, 1989

Autoimmune T cells: immune recognition of normal and variant peptide epitopes and peptide-based therapy

J L UrbanL Hood


Experimental autoimmune encephalomyelitis (EAE) results from T helper (TH) cell recognition of myelin basic protein (MBP). We have characterized TH cell reactivity in B10.PL and PL/J (H-2u) mice to 39 N-terminal MBP peptide derivatives of different lengths and with individual amino acid substitutions. The peptide determinant of murine MBP can be divided into a minimal stimulatory core region (residues 1-6) and a tail region (residues 7-20) that alters the structure of the core region to affect both T cell recognition and MHC binding. Core recognition by B10.PL and PL/J mice is highly similar but in one case strain dependent. Peptide analogs that do not stimulate MBP-specific TH cells but bind to the I-Au molecule competitively inhibit T cell reactivity to MBP in vitro and prevent the induction of EAE in vivo.

Mentioned in this Paper

Antigenic Specificity
Experimental Autoimmune Encephalomyelitis
Lymphocyte Activation
Myelin Basic Proteins
Myelin Basic Protein, Isoform 4
Autoimmune Diseases

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