Autoimmune T cells lured to a FASL web of death by MSCs

Cell Stem Cell
William J Murphy, Jan A Nolta

Abstract

Achieving immune tolerance through cell transplantation is a promising approach for treating autoimmune disease. In this issue of Cell Stem Cell, Akiyama et al. (2012) demonstrate that human and mouse mesenchymal stem cells can induce immune suppression by attracting and killing autoreactive T cells, which stimulates TGFb production by macrophages and generates regulatory T cells.

References

May 13, 2008·Lancet·Katarina Le BlancUNKNOWN Developmental Committee of the European Group for Blood and Marrow Transplantation
Jul 3, 2010·Stem Cells·Jakub TolarBruce R Blazar
Oct 6, 2010·Advanced Drug Delivery Reviews·Todd MeyerroseJan A Nolta
Jul 6, 2011·Cell Stem Cell·Arnold I Caplan, Diego Correa

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