PMID: 6976036May 1, 1981Paper

Autoimmune thrombocytopenia in dogs and cats

The Veterinary Clinics of North America. Small Animal Practice
N C Jain, J W Switzer

Abstract

Autoimmune thrombocytopenia has been recognized as a distinct entity in the dog and cat. It is characterized by: (1) clinical signs of thrombocytopenia, such as hemorrhages into the skin and tissues and from body orifices, (2) coagulation defects related to thrombocytopenia, such as prolonged bleeding time and poor clot retraction, (3) hematologic changes such as severe to moderate thrombocytopenia, often blood loss anemia, and signs of increased erythropoiesis, and (4) an absence or decreased number of megakaryocytes in the bone marrow during early phase and increased number during compensatory phase. Megakaryocytes may also show morphologic abnormalities. Serologic diagnosis of AITP in the dog and cat currently involves demonstration of antiplatelet antibody in serum by PF-3 test and/or associated with marrow megakaryocytes by a technique of direct immunofluorescence. Circumstances leading to formation of antiplatelet antibody remain unknown. Immune-mediated platelet destruction is believed to occur in the reticuloendothelial system, primarily in the spleen. Treatment consists primarily of corticosteroids and other immunosuppressive drugs. Dogs with primary AITP generally respond favorably to such therapy.

References

Sep 1, 1976·British Journal of Haematology·R L DonnellA L Lightsey
Dec 1, 1977·CRC Critical Reviews in Clinical Laboratory Sciences·R McMillan
Aug 1, 1979·British Journal of Haematology·M LeporrierJ L Binet
Apr 5, 1979·The New England Journal of Medicine·J G KeltonJ Hirsh
Mar 6, 1978·JAMA : the Journal of the American Medical Association·M J StuartF R Davey
May 26, 1978·JAMA : the Journal of the American Medical Association·J MorrisonD Newman
Jun 9, 1978·JAMA : the Journal of the American Medical Association·R McMillanR L Longmire
Feb 1, 1978·The Journal of Infectious Diseases·J W HarveyJ M Gaskin
Oct 1, 1975·British Journal of Haematology·R H Dixon, W F Rosse
Aug 22, 1974·The New England Journal of Medicine·Y S AhnC S Eytel

❮ Previous
Next ❯

Citations

Mar 26, 2010·Annals of Hematology·John W Semple
Jan 31, 2012·The Veterinary Clinics of North America. Small Animal Practice·Michael O Childress
Aug 14, 2013·British Journal of Haematology·Christopher G J McKenzieJohn W Semple
Dec 31, 2002·The Veterinary Journal·R MischkeL Kreienbrock
Nov 1, 1995·The Veterinary Clinics of North America. Small Animal Practice·E Rudloff
Jan 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·B F FeldmanN C Jain
Jan 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·S C Helfand
May 25, 2002·Veterinary Clinical Pathology·Douglas J. Weiss, Betsy Aird
Jan 5, 2010·Journal of the American Animal Hospital Association·Christina WondratschekBarbara Kohn
Nov 21, 2007·Journal of the American Veterinary Medical Association·Matthew D Miller, Katharine F Lunn
Sep 3, 2008·Journal of the American Animal Hospital Association·Jutta C Putsche, Barbara Kohn
Sep 1, 1985·Veterinary Pathology·J C BloomL Z Saunders

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Indian Journal of Cancer
K N NareshA J Veliath
Minerva ginecologica
R Anselmi AngeliG Plotti
Acta Medica Croatica : C̆asopis Hravatske Akademije Medicinskih Znanosti
T VukB Jaksić
© 2021 Meta ULC. All rights reserved