Autoimmune thyroid disease induced by thyroglobulin and lipopolysaccharide is inhibited by soluble TNF receptor type I

European Journal of Immunology
P ZacconeA Cooke

Abstract

Experimental autoimmune thyroiditis (EAT) is inducible in mice by immunization with thyroglobulin and adjuvant. Previous studies have shown that EAT is an autoimmune Th1-mediated disease but its characteristics differ with the adjuvant. Granulomatous lesions with marked follicular disruption develop following administration of thyroglobulin (Tg) and complete Freund's adjuvant (CFA) whereas when lipopolysaccharide (LPS) is used as the adjuvant only focal infiltrates of mononuclear cells are observed. The pro-inflammatory cytokine, TNF-alpha, is associated with Th1 autoimmune-mediated conditions. Cytokine antagonists have been used as potential therapeutic agents in several experimental autoimmune models. Soluble cytokine receptors belong to this category and may naturally be shed from cell membranes to inhibit cytokine activity. We show that the administration of the soluble TNF receptor type I (sTNFR I) in the induction of EAT has very different effects on the two models of induced autoimmune thyroiditis. sTNFR I treatment inhibits the induction of EAT only when mouse Tg is given with LPS not with CFA, suggesting an important difference in the pathogenic processes.

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Citations

Aug 29, 2009·Neurocritical Care·Dannielle ZierathKyra J Becker
Dec 18, 2009·Nature Immunology·Kajsa Wing, Shimon Sakaguchi
Oct 16, 2004·Memórias do Instituto Oswaldo Cruz·Maria Ilma AraújoEdgar M Carvalho
Aug 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea P MartinSergio A Lira
Mar 26, 2005·Immunological Reviews·Adrian ListonChristopher C Goodnow
Mar 14, 2008·International Journal of Immunopathology and Pharmacology·M PapazahariadouS Frydas
Nov 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milica LazarevićĐorđe Miljković

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