Autoimmune thyroiditis following HLA-matched sibling hematopoietic stem cell transplantation for Wiskott-Aldrich syndrome

Pediatric Transplantation
Tristan KnightSüreyya Savaşan

Abstract

WAS is a fatal X-linked combined immunodeficiency syndrome, the only cures for which are HSCT or gene therapy. AID occur in up to 72% of patients with WAS who do not receive HSCT, likely arising secondary to impaired multilineage immune autoregulatory function; AITD is not typically seen. In this article, we describe the case of a male patient who underwent HLA-matched HSCT for WAS at the age of 5 months, with his sister (a WAS carrier) acting as his donor and subsequently developed AITD 12 months post-transplant, with marked elevation of antithyroid peroxidase antibody titer. His donor sister was subsequently found to have elevated antithyroid peroxidase antibody titer with increasing trend and normal thyroid function. Although several mechanisms exist by which our patient may have developed AITD, we suggest the transfer of autoreactive donor immune cells as the most plausible explanation.

References

Apr 1, 1989·The Journal of Clinical Investigation·P D Nisen, P G Waber
Dec 22, 1983·The New England Journal of Medicine·C I SmithG Matell
Sep 1, 1995·European Journal of Pediatrics·B Latal HajnalF Berthet
Nov 25, 1998·Bone Marrow Transplantation·Y Sherer, Y Shoenfeld
Aug 30, 2002·British Journal of Haematology·Hirokazu InoueMitsuoki Eguchi
Dec 7, 2002·Journal of Pediatric Hematology/oncology·José L OlivaresManuel Bueno
Sep 13, 2003·Blood·Kohsuke ImaiShigeaki Nonoyama
Jan 11, 2005·Bone Marrow Transplantation·W Y AuY L Kwong
Feb 14, 2007·The Journal of Experimental Medicine·Francesco MarangoniLoïc Dupré
May 13, 2008·Lancet·Katarina Le BlancUNKNOWN Developmental Committee of the European Group for Blood and Marrow Transplantation
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Nov 1, 2007·Current Genomics·S C L Gough, M J Simmonds
Mar 20, 2012·Bone Marrow Transplantation·C R ShinA H Filipovich
Jan 23, 2013·The Journal of Experimental Medicine·Francesca PreteFederica Benvenuti
Dec 29, 2013·Journal of Autoimmunity·Maria Carmina CastielloMirjam van der Burg
Feb 28, 2014·TheScientificWorldJournal·Abdalla KhalilMyriam Weyl Ben-Arush
Apr 22, 2015·JAMA : the Journal of the American Medical Association·Salima Hacein-Bey AbinaMarina Cavazzana

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Citations

Aug 28, 2021·The Application of Clinical Genetics·Murugan SudhakarSurjit Singh

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