Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles

PloS One
Arsen ArakelyanHans Binder

Abstract

Autoinflammatory and autoimmune disorders are characterized by aberrant changes in innate and adaptive immunity that may lead from an initial inflammatory state to an organ specific damage. These disorders possess heterogeneity in terms of affected organs and clinical phenotypes. However, despite the differences in etiology and phenotypic variations, they share genetic associations, treatment responses and clinical manifestations. The mechanisms involved in their initiation and development remain poorly understood, however the existence of some clear similarities between autoimmune and autoinflammatory disorders indicates variable degrees of interaction between immune-related mechanisms. Our study aims at contributing to a holistic, pathway-centered view on the inflammatory condition of autoimmune and autoinflammatory diseases. We have evaluated similarities and specificities of pathway activity changes in twelve autoimmune and autoinflammatory disorders by performing meta-analysis of publicly available gene expression datasets generated from peripheral blood mononuclear cells, using a bioinformatics pipeline that integrates Self Organizing Maps and Pathway Signal Flow algorithms along with KEGG pathway topologies. The results ...Continue Reading

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Citations

Nov 18, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Qiao PengGang Zhou
Feb 15, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susann WinterUwe Platzbecker
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Dec 18, 2019·Pharmaceutics·Arsen ArakelyanHans Binder
Sep 19, 2020·Rheumatology·Marianna MitratzaAnton E Kunst
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Jan 22, 2021·Bioconjugate Chemistry·Deepak KarnaHanbin Mao
Feb 3, 2021·International Journal of Molecular Sciences·Arsen ArakelyanHans Binder
Jul 2, 2021·Clinical Epidemiology·Bente Mertz NørgårdJens Fedder
Jul 15, 2021·Journal of Ophthalmology·Jasmine Y SerpenLev Prasov
Aug 31, 2021·Current Opinion in Otolaryngology & Head and Neck Surgery·Nadia L SamahaMichael Hoa

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Datasets Mentioned

BETA
GSE3365
GSE48378
U133A

Methods Mentioned

BETA
chip

Software Mentioned

R
R package “
R package “ igraph ”
R “ igraph ”
Affymetrix MAS5
REVIGO
oligo
Webgestalt
SOM
affy

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