Autoimmunity and intestinal colonization by Candida albicans in patients with type 1 diabetes at the time of the diagnosis

Korean journal of pediatrics
Semra GürsoyErdal Adal

Abstract

Type 1 diabetes mellitus (T1DM) is a chronic and immune-mediated disease, which is characterized by the progressive destruction of pancreatic beta cells. T1DM precipitates in genetically susceptible individuals through environmental factors. In this study, we aimed to evaluate the impact of autoimmunity and intestinal colonization of Candida albicans on the development of T1DM. Forty-two patients newly diagnosed with T1DM and 42 healthy subjects were included in this monocentric study. The basic and clinical characteristics of the patients were recorded. T1DM-, thyroid-, and celiac-associated antibodies were evaluated. Stool cultures for C. albicans were performed to assess whether or not gut integrity was impaired in patients with T1DM. The evaluation of T1DM- and thyroid-associated antibodies showed that the prevalences of islet cell antibodies and antithyroperoxidase positivity were higher in the study patients than in the patients in the control group. Furthermore, the direct examination and culture of fresh stool samples revealed that 50% of the patients with T1DM and 23.8% of the control subjects had fungi (C. albicans). Through this study, we suggest that the presence of intestinal C. albicans colonization at the time of...Continue Reading

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Citations

Jan 13, 2019·Journal of Clinical Medicine·Célia F RodriguesMariana Henriques
Mar 19, 2020·Frontiers in Immunology·Thomas WhalleyBarbara Szomolay
Nov 7, 2019·Nutrients·Chiara PellicanoEdoardo Rosato
Jan 16, 2019·International Journal of Molecular Sciences·Elena Gianchecchi, Alessandra Fierabracci
Nov 17, 2020·Frontiers in Immunology·Eric MariettaJoseph A Murray
May 7, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Awgichew Shewasinad Yehualashet, Berhan Begashaw Yikna

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Methods Mentioned

BETA
biopsy
cesarean section

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