PMID: 18406789Mar 1, 1997Paper

Autoimmunity and type I diabetes

Trends in Endocrinology and Metabolism : TEM
J F Bach

Abstract

Insulin-dependent diabetes mellitus (IDDM) is a T-cell-mediated autoimmune disease. The effector mechanisms essentially involve cytokine-mediated inflammation ultimately leading to beta-cell destruction. Several candidate autoantigens have been delineated for both the pathogenic T-cell response and the nonpathogenic antibody response used for disease prediction. Because of antigen spreading, it is not yet clear which of these antigens are involved in the triggering of the autoimmune response. In any case, this TH1 autoimmune response is amplified and perpetuated by an immune dysregulation involving TH2 cells. Both effector and regulatory mechanisms are placed under the tight control of major histocompatibility complex (MHC) and non-MHC genes. (Trends Endocrinol Metab 1997; 8:71-74). (c) 1997, Elsevier Science Inc.

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Citations

Dec 23, 2006·Clinical and Experimental Pharmacology & Physiology·R T NarendhirakannanM Kandaswamy
Feb 22, 2012·Indian Journal of Pharmacology·Hyo Won JungYong-Ki Park
Mar 17, 2010·Expert Opinion on Biological Therapy·Johnny Ludvigsson
Mar 10, 2009·Diabetes/metabolism Research and Reviews·Johnny Ludvigsson
Dec 29, 2004·Diabetes Research and Clinical Practice·Mi-Kyung LeeMyung-Sook Choi
Feb 11, 2010·Journal of Diabetes Science and Technology·Johnny Ludvigsson, UNKNOWN Linköping Diabetes Immune Intervention Study Group
Jul 23, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Seung-Hee LeeIn-Sun Park
May 28, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Junbao YangWilliam W Kwok

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