Autoimmunity conferred by chs3-2D relies on CSA1, its adjacent TNL-encoding neighbour

Scientific Reports
Fang XuXin Li

Abstract

Plant innate immunity depends on the function of a large number of intracellular immune receptor proteins, the majority of which are structurally similar to mammalian nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) proteins. CHILLING SENSITIVE 3 (CHS3) encodes an atypical Toll/Interleukin 1 Receptor (TIR)-type NLR protein with an additional Lin-11, Isl-1 and Mec-3 (LIM) domain at its C-terminus. The gain-of-function mutant allele chs3-2D exhibits severe dwarfism and constitutively activated defense responses, including enhanced resistance to virulent pathogens, high defence marker gene expression, and salicylic acid accumulation. To search for novel regulators involved in CHS3-mediated immune signaling, we conducted suppressor screens in the chs3-2D and chs3-2D pad4-1 genetic backgrounds. Alleles of sag101 and eds1-90 were isolated as complete suppressors of chs3-2D, and alleles of sgt1b were isolated as partial suppressors of chs3-2D pad4-1. These mutants suggest that SAG101, EDS1-90, and SGT1b are all positive regulators of CHS3-mediated defense signaling. Additionally, the TIR-type NLR-encoding CSA1 locus located genomically adjacent to CHS3 was found to be fully required for chs3-2D-mediated autoimmunity...Continue Reading

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Citations

Apr 30, 2016·The New Phytologist·Simon Bernard SaucetDaniel Esmenjaud
Jun 25, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Zane DuxburyPanagiotis F Sarris
Jun 23, 2018·Plant & Cell Physiology·Shachi JoglekarErich Kombrink
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Jun 19, 2017·Planta·Vikas Srivastava, Praveen Kumar Verma
Dec 18, 2019·Journal of Integrative Plant Biology·Wei WangDingzhong Tang
Sep 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yan MaJonathan D G Jones
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Aug 24, 2019·Cell·Anna-Lena Van de WeyerFelix Bemm
Apr 14, 2021·Plant Physiology·Lu-Shen LiSha Li

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Methods Mentioned

BETA
PCR
ubiquitination

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