PMID: 2491644Jan 1, 1989Paper

Autoimmunity, HLA, Gm and Km polymorphisms in Turner's syndrome

Autoimmunity
D LarizzaF Severi

Abstract

Considering the high frequency of autoimmune disorders in Turner's syndrome and the close relationship between autoimmunity, HLA and immunoglobulin constant region gene polymorphisms, we studied 46 patients with Turner's syndrome, by determination of autoantibodies, HLA histoglobulins and Gm and Km allotypes. OSA and in particular PCA resulted significantly more frequent in patients than in the controls. A higher frequency of HLA-A31, B38 antigens and of blanks at HLA-A locus was found in Turner's subjects than in the controls. A31 was significantly more frequent in autoantibody positive patients while B38 was more frequent in autoantibody negative Turner's subjects than in the controls. DR4 antigen was present only in autoantibody negative patients. Gm 3; 23; 5* phenotype was significantly less frequent, while Gm 3;..; 5* phenotype was more frequent in patients than in controls. Our data confirm the higher incidence of autoimmunity disorders in Turner's syndrome than in normal subjects. Particular HLA and immunoglobulin types seem to mark this condition. The increase in the blank frequency at A locus could be explained by the presence of a rare antigen at HLA-A locus or a particularly elevated homozygous condition in these sub...Continue Reading

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Citations

Mar 1, 1992·European Journal of Pediatrics·L CortonaR Lorini
Apr 20, 2007·Rheumatology International·Onur ArmaganCengiz Oner
Aug 26, 1998·Immunology Today·J J Stewart
Feb 25, 1998·Journal of Clinical Epidemiology·C H GravholtJ Hansen
Oct 22, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Daniela LarizzaFrancesca Severi
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Claus Højbjerg Gravholt
Nov 10, 2005·Journal of Endocrinological Investigation·M WasniewskaUNKNOWN Italian Study Group for Turner Syndrome
Feb 5, 2002·Expert Opinion on Pharmacotherapy·C H Gravholt
Dec 14, 2011·Autoimmunity Reviews·Ana LleoPietro Invernizzi
Apr 8, 2009·Journal of Autoimmunity·Daniela LarizzaMiryam Martinetti
Apr 21, 2004·Journal of the American Academy of Dermatology·Eve J LowensteinSharon A Glick
Jan 1, 1993·Diabetes Research and Clinical Practice·R LoriniF Severi
Jan 10, 2002·European Journal of Human Genetics : EJHG·M KveiborgM Kassem
Oct 1, 1994·Clinical Genetics·B FilipovićJ Vuković
Dec 1, 1990·Clinical Genetics·M CucciaF Severi

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