Genetic susceptibility, environmental factors and immune mechanisms are implicated in the pathogenesis and etiology of insulin-dependent diabetes mellitus. The onset of the disease is associated with a major loss of beta cells, and inflammatory cells may be seen in and around the islets of Langerhans. Insulin-dependent diabetes is often associated with autoimmune endocrinopathies. Antipancreatic cell-mediated autoimmunity is found predominantly in young patients with insulin-dependent diabetes of recent onset as are antibodies reactive with cytoplasmic components or cell surface determinants of islet cells. Antibodies reactive with live islet cells may mediate complement-dependent cytotoxicity. The antigen(s) in the islet cells remain(s) to be identified and characterized. Further studies will be necessary to determine whether autoimmunity is the cause of beta-cell destruction or whether it is a consequence of damages caused by exogenous agents in susceptible persons.
H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;
Islet cell survival determined by morphology. An immunocytochemical study of the islets of Langerhans in juvenile diabetes mellitus
Pancreatic islet-cell antibodies in diabetes mellitus correlated with the duration and type of diabetes, coexistent autoimmune disease, and HLA type
Insulin and glucagon secretion in diabetic and non-diabetic patients with circulating islet cell antibodies
Complement-fixing islet-cell antibodies in type-I diabetes: possible monitors of active beta-cell damage
Glucose and insulin responses to oral glucose in overt non-insulin-dependent diabetics with and without the islet cell antibody
Block in insulin release from column-perifused pancreatic beta-cells induced by islet cell surface antibodies and complement
The effect of fish-oil on the remission of type 1 (insulin-dependent) diabetes in newly diagnosed patients
Maternal-child blood group incompatibility and other perinatal events increase the risk for early-onset type 1 (insulin-dependent) diabetes mellitus
Increased reduction in fasting C-peptide is associated with islet cell antibodies in type 1 (insulin-dependent) diabetic patients
The influence of cyclosporin A on the vascular permeability of the pancreatic islets and on diabetes induced by multiple low doses of streptozotocin in the mouse
Relation between T-cell responses to glutamate decarboxylase and coxsackievirus B4 in patients with insulin-dependent diabetes mellitus
Polymorphism in the 5' flanking region of the human insulin gene: a genetic marker for non-insulin-dependent diabetes
Identification of multiple genes in bovine retinal pericytes altered by exposure to elevated levels of glucose by using mRNA differential display
Membranoproliferative glomerulonephritis associated with type 1 diabetes mellitus and Hashimoto's thyroiditis
Comparison of whole pancreas and pancreatic islet transplantation in controlling nephropathy and metabolic disorders of diabetes
Modulation of the effect of humoral-mediated cytotoxicity on isolated rat pancreatic islets by glucose
Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes
Application of the time-resolved immunofluorometric assay to the study of C3 complement component glycation in vitro and in vivo
ICA and organ-specific autoantibodies among Japanese patients with early-onset insulin-dependent diabetes mellitus--the JDS study
Breast-feeding seems to play a marginal role in the prevention of insulin-dependent diabetes mellitus
The genetic susceptibility to insulin-dependent diabetes mellitus: combined segregation and linkage analysis
Increased risk for type I (insulin-dependent) diabetes in relatives of patients with alopecia areata (AA)
Myasthenia gravis with thymoma is not associated with an increased incidence of non-muscle autoimmune disorders
B-cell function and islet cell and other organ-specific autoantibodies in relatives to insulin-dependent diabetic patients
Interferon-gamma increases the sensitivity of islets of Langerhans for inducible nitric-oxide synthase expression induced by interleukin 1.
Detection of antibodies against wheat germ agglutinin bound glycoproteins on the islet-cell membrane
Thyroid autoantibodies in black and in white children and adolescents with type 1 diabetes mellitus and their first degree relatives
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