PMID: 9546812Jan 1, 1997Paper

Autoimmunity to ryanodine receptor and titin in myasthenia gravis is associated with GM allotypes

Autoimmunity
G O SkeieN E Gilhus

Abstract

Myasthenia gravis (MG) is mediated by autoantibodies against the acetylcholine receptor at the muscle endplate. Some MG patients have in addition antibodies (Ab) to the skeletal muscle proteins ryanodine receptor (RyR) and titin. We have examined GM and KM allotypes, RyR and titin Ab in 44 MG patients (37 thymoma patients and 7 non-thymoma, late-onset patients) and 292 non-MG controls to see if GM/KM allotypes associate with differences in autoantibody production. All patients had titin Ab, and 15 thymoma patients had also RyR Ab. The phenotype GM 1, 2, 3 23 5, 21 was significantly increased in the patients with titin Ab compared with the non-MG controls (chi2 = 4.93, p < 0.05). Thymoma patients with RyR Ab had a higher frequency of the GM 3 23 5 phenotype compared with RyR Ab negative patients and controls (chi2 = 7.1, p < 0.05). KM allotypes did not differ between RyR Ab positive or titin Ab positive patients and controls. GM phenotypes may thus be associated with an autoimmune response against the muscle proteins titin and RyR in MG patients.

References

Oct 1, 1992·Annals of Neurology·A MyglandN E Gilhus
Jun 1, 1990·Journal of Autoimmunity·N E GilhusJ A Aarli
Feb 1, 1989·Scandinavian Journal of Immunology·H SarvasO Mäkelä
Jan 1, 1988·Advances in Immunology·J LindstromY Fujii
Feb 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·H C ChiuT P Hung
Apr 1, 1986·European Journal of Pediatrics·Y IwaiH Mikawa
Jan 1, 1986·Neurology·J Murphy, S F Murphy
Dec 1, 1984·Neurology·C I SmithR Pirskanen
Feb 1, 1983·Journal of Immunogenetics·C I SmithG Matell
Oct 1, 1995·Journal of Neuroimmunology·A MyglandN E Gilhus
Feb 1, 1995·Clinical and Experimental Immunology·V A OxeliusL A Hanson
Mar 1, 1994·Neurology·J BergoffenK H Fischbeck
Jul 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·A MyglandN E Gilhus
Dec 1, 1993·Current Opinion in Immunology·N Willcox
Feb 1, 1993·Scandinavian Journal of Immunology·V A Oxelius

❮ Previous
Next ❯

Citations

Aug 26, 2000·Mechanisms of Ageing and Development·E MocchegianiF Licastro
Apr 1, 1998·Journal of Neuroimmunology·G RaknesC Vedeler
Jun 20, 2001·Acta Physiologica Scandinavica·G O SkeieN E Gilhus
Mar 21, 2009·Journal of Neuroimmunology·Espen Homleid AlsethGeir Olve Skeie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.