Autoimmunity to the voltage-gated calcium channel underlies the Lambert-Eaton myasthenic syndrome, a paraneoplastic disorder.

Trends in Neurosciences
A VincentJ Newsom-Davis

Abstract

The Lambert-Eaton myasthenic syndrome (LEMS) is a disorder of neuromuscular transmission, often associated with small cell lung carcinoma (SCLC), and characterized by reduced quantal release of acetylcholine from the motor nerve terminals. Another neuromuscular transmission disorder, myasthenia gravis, has a well-understood autoimmunological cause. This review discusses the evidence for a similar autoimmunological effect in the development of LEMS. Injection of LEMS IgG into mice passively transfers the physiological and morphological abnormalities, which include paucity and disorganized arrangement of active zone particles believed to represent the voltage-gated calcium channels (VGCCs). Calcium influx via VGCCs into SCLC cells is reduced by LEMS IgG suggesting that in SCLC-associated LEMS, antibodies may be triggered by VGCCs expressed on these cells; this immunological cross-reactivity may lead to the neurological abnormality. Similar VGCCs on neuronally derived cells may trigger the disorder in those without a tumour. The disorder provides another example of the complicated relationships between the nervous and immune systems and tumorigenic processes.

References

Jul 1, 1977·The Journal of Pathology·A S TischlerB Biales
Jan 1, 1979·The Japanese Journal of Physiology·T MorimotoY Tanaka
Feb 15, 1988·Biochemical and Biophysical Research Communications·J BarhaninM Lazdunski
Oct 1, 1988·Trends in Neurosciences·K P CampbellA H Sharp
Oct 1, 1988·Trends in Neurosciences·R W TsienA P Fox
Oct 1, 1988·Trends in Neurosciences·S J Smith, G J Augustine
Jun 1, 1989·Journal of Autoimmunity·J Newsom-DavisJ B Rothbard
Jan 1, 1989·Annals of the New York Academy of Sciences·D W WrayC Peers
Jun 1, 1988·Brain : a Journal of Neurology·J H O'NeillJ Newsom-Davis
Jan 1, 1988·Annals of the New York Academy of Sciences·B LangJ Newsom-Davis
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R HohlfeldB M Conti-Tronconi
Jun 1, 1985·Annals of Neurology·C PriorJ Newsom-Davis
Oct 1, 1988·Journal of Child Neurology·A G Engel
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S J TzartosB M Conti-Tronconi
Jan 1, 1987·Annals of the New York Academy of Sciences·T R Johns
Aug 1, 1987·Brain : a Journal of Neurology·H J OosterhuisD W Wray
Nov 1, 1987·Journal of the Neurological Sciences·M TsujihataS Nagataki
Dec 20, 1985·Science·B M OliveraL J Cruz
Sep 1, 1965·Brain : a Journal of Neurology·P C Wilkinson, J Zeromski

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Citations

Mar 15, 2000·Muscle & Nerve·J M Lindstrom
Mar 1, 1991·Annals of Neurology·K LeysJ Newsom-Davis
Oct 23, 1997·Annals of Neurology·D A Greenberg
Dec 1, 1991·Muscle & Nerve·V ChaudhryD R Cornblath
Jan 1, 1996·Pflügers Archiv : European journal of physiology·J Molgó, J M Guglielmi
Dec 13, 1997·Molecular Neurobiology·J Lindstrom
Aug 30, 2008·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Steven Vernino
Jan 12, 2013·Current Treatment Options in Neurology·Jean-Christophe Antoine, Jean-Philippe Camdessanché
Sep 1, 1993·Journal of the Neurological Sciences·S H AppelE Stefani
Jul 1, 1994·Journal of the Neurological Sciences·S H AppelE Stefani
Oct 1, 1990·Trends in Pharmacological Sciences·B Demeneix
Oct 1, 1991·Current Opinion in Neurobiology·J Newsom-Davis, A Vincent
Jan 16, 2003·Physiology & Behavior·Robert E Poage, Stephen D Meriney
Feb 23, 2000·Neuroscience Research·M TakamoriK Komai
Mar 29, 2001·Progress in Neurobiology·S J Wood, C R Slater
Feb 6, 2013·Acta Pharmacologica Sinica·Han Sun, Min Li
Dec 10, 1992·The New England Journal of Medicine·R G SmithS H Appel
Aug 2, 2013·The New England Journal of Medicine·Walter D ConwellWilliam J Janssen
Feb 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yaping Joyce LiaoRichard W Tsien
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·C LevequeN Martin-Moutot
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·R G SmithS H Appel
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Chris PeersHugh A Pearson
Apr 1, 1992·Acta Physiologica Scandinavica·J J PancrazioY I Kim
Jun 21, 1993·Annals of the New York Academy of Sciences·E SherF Clementi
Jun 21, 1993·Annals of the New York Academy of Sciences·M P ViglioneY I Kim
Dec 20, 1993·Annals of the New York Academy of Sciences·O el FarM J Seagar
Aug 14, 1997·Annals of the New York Academy of Sciences·P M Moore
Jul 22, 1999·Annals of the New York Academy of Sciences·K L EngischM C Nowycky
Sep 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·G M ElringtonJ Newsom-Davis
Apr 15, 1999·Annual Review of Neuroscience·K D Whitney, J O McNamara
Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tyler B TarrStephen D Meriney
Jun 1, 1997·Journal of Endocrinological Investigation·M OzataM A Gundogan

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