Autoimmunity: when self-tolerance breaks down

Current Biology : CB
D L Mueller, M K Jenkins

Abstract

The spontaneous development of destructive polyarthritis in mice transgenic for an autoreactive T-cell receptor supports the notion that a failure of T-cell self-tolerance can lead to similar diseases in humans, and sheds new light on the role of peripheral tolerance in the avoidance of such pathological immune responses.

References

Jun 1, 1990·Arthritis and Rheumatism·G S Firestein, N J Zvaifler
Jun 1, 1995·Current Opinion in Immunology·D L Mueller, M K Jenkins
Dec 1, 1994·Current Opinion in Immunology·J F Miller, R A Flavell
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·A MondinoM K Jenkins
Nov 29, 1996·Cell·V KouskoffD Mathis
Oct 29, 2008·Annual Review of Pathology·John B Imboden

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Citations

Mar 27, 2003·Trends in Molecular Medicine·Uri NevoMichal Schwartz
Nov 24, 2004·Infection and Immunity·Brad GilbertsonChristina Cheers
Jul 28, 2007·Journal of Computer-aided Molecular Design·Erik EvensenMartin Karplus

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