Autoimplants in serous borderline tumors of the ovary: a clinicopathologic study of 30 cases of a process to be distinguished from serous adenocarcinoma

The American Journal of Surgical Pathology
Sarah E RollinsDebra A Bell

Abstract

The clinical and pathologic features of serous borderline tumors (SBTs) with autoimplants (AIs) were studied with emphasis on their relation to survival, ovarian SBT with a micropapillary pattern, and their distinction from serous adenocarcinoma. The 30 patients ranged in age from 17 to 70 years (mean, 35.8 years). Two had stage I disease, 10 had stage II disease, and 18 had stage III disease. Twenty-five patients had bilateral ovarian tumors. In 28 cases, AIs were present on the surface of the neoplasm or between exophytic surface tumor papillae; in 2 cases, AIs were between papillae within intracystic tumor. The AIs consisted of single cells or glands and clusters of cells with mild to moderate nuclear atypia within a fibroblastic stroma; the stroma dominated over the epithelium in extent within the AI. In many cases, the epithelial cells in the AI had abundant eosinophilic cytoplasm. All but 2 of the patients had coexisting noninvasive peritoneal implants; 3 of them also had invasive peritoneal implants. Six of the SBTs had a micropapillary pattern; 3 of these were stage III and 3 stage II tumors. Clinical follow-up was available for 11 patients. Eight were alive and well after 4 to 7 years (mean, 5 years); 3 of these patien...Continue Reading

References

Sep 10, 2002·The American Journal of Surgical Pathology·Michael T DeaversElvio G Silva
Dec 24, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·C Blake GilksDianne M Miller
May 27, 2003·The American Journal of Surgical Pathology·Ann E Smith SehdevRobert J Kurman
Nov 15, 2003·International Journal of Surgical Pathology·Russell Vang, Fattaneh A Tavassoli

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Citations

Nov 10, 2009·The American Journal of Surgical Pathology·Bojana Djordjevic, Anais Malpica
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Robert E EmersonLiang Cheng
Jun 23, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·James A Kraus, Jeffrey D Seidman
Mar 26, 2009·Magyar onkologia·Ildikó VereczkeyZsolt Orosz
May 23, 2012·The American Journal of Surgical Pathology·Bojana Djordjevic, Anais Malpica
May 14, 2009·British Journal of Cancer·A CoumbosUNKNOWN North-Eastern German Society of Gynecological Oncology (NOGGO)
Aug 11, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Georgia KarpathiouMichel Peoc'h
Nov 28, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jeffrey D SeidmanRobert J Kurman

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