PMID: 6984432Dec 15, 1982Paper

Autoinduction of differentiation in WEHI-3B leukemia cells

International Journal of Cancer. Journal International Du Cancer
D Metcalf, N A Nicola

Abstract

Cells of the differentiation-responsive mouse myelomonocytic leukemia cell line WEHI-3B D+ form colonies in agar exhibiting a low frequency of spontaneous differentiation mainly in the macrophage pathway. Compared with undifferentiated colonies, spontaneously differentiating colonies have a reduced content of clonogenic cells and surviving clonogenic cells tend themselves to form differentiating colonies, both being characteristics of differentiated colonies induced by the regulator, granulocyte colony-stimulating factor, G-CSF. Colony crowding increased the frequency of spontaneously differentiating colonies and WEHI-3B D+ colony cells were shown to release material able to induce differentiation in WEHI-3B D+ colonies. Cells from spontaneously differentiating D+ colonies were not hyperresponsive to the induction of differentiation by G-CSF and did not release larger amounts of differentiation-inducing material than did cells from undifferentiated colonies. Cells of the differentiation-unresponsive WEHI-3B D-line produced similar amounts of differentiation-inducing material to those produced by D+ cells. Apparently spontaneous differentiation in WEHI-3B D+ colonies seems most likely to be due to exposure of the colony-forming ...Continue Reading

References

Nov 15, 1979·International Journal of Cancer. Journal International Du Cancer·D Metcalf
Feb 15, 1980·International Journal of Cancer. Journal International Du Cancer·D Metcalf
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·A Falk, L Sachs
Aug 15, 1982·International Journal of Cancer. Journal International Du Cancer·D Metcalf

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Citations

Jun 1, 1988·Cancer Metastasis Reviews·A BomirskiJ Bigda
Jan 1, 1989·Progress in Growth Factor Research·W P Steward, J H Scarffe
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N A Nicola, D Metcalf
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D ZiporiT Oren
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·N M GoughD Metcalf
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A F Wilks
Jan 1, 1996·Microbiology and Immunology·T TanigawaY Tanaka
Jan 1, 1990·American Journal of Reproductive Immunology : AJRI·J A Hill
Jan 1, 1987·International Journal of Cell Cloning·N A Nicola
Jan 15, 1987·International Journal of Cancer. Journal International Du Cancer·C G BegleyN A Nicola
Jun 1, 1986·Australian and New Zealand Journal of Medicine·P Hersey
Jan 1, 1987·Journal of Cellular Physiology. Supplement·N A Nicola
Aug 1, 1985·Journal of Cellular Physiology·N A Nicola, D Metcalf
Mar 1, 1984·Immunology Today·N A Nicola, M Vadas
May 22, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D Metcalf
Mar 12, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D Metcalf
Dec 17, 1989·Biochimica Et Biophysica Acta·J H Pierce

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