Autoinhibitory and other autoregulatory elements within the dynein motor domain

Journal of Structural Biology
Richard B Vallee, Peter Höök

Abstract

The dyneins are a family of microtubule motor proteins. The motor domain, which represents the C-terminal 2/3 of the dynein heavy chain, exhibits homology to the AAA family of ATPases. It consists of a ring of six related but divergent AAA+ units, with two substantial sized protruding projections, the stem, or tail, which anchors the protein to diverse subcellular sites, and the stalk, which binds microtubules. This article reviews recent efforts to probe the mechanism by which the dyneins produce force, and work from the authors' lab regarding long-range conformational regulation of dynein enzymatic activity.

References

Sep 1, 1988·The Journal of Cell Biology·H S ShpetnerR B Vallee
Nov 12, 1987·Nature·B M Paschal, R B Vallee
Dec 25, 1984·Journal of Molecular Biology·U Goodenough, J Heuser
Feb 1, 1996·Current Opinion in Cell Biology·M E Porter
May 5, 1998·Journal of Molecular Biology·M SamsóM P Koonce
Feb 11, 1999·The Journal of Cell Biology·G J PazourG B Witman
Mar 9, 1999·Molecular Biology of the Cell·M E PorterW Dentler
Sep 22, 2001·The EMBO Journal·A StraubeG Steinberg
Mar 22, 2002·Molecular Biology of the Cell·Paula M GrissomJ Richard McIntosh
Nov 15, 2002·Journal of Cell Science·Atsushi MikamiRichard B Vallee
Mar 1, 2003·Nature·Stan A BurgessKazuhiro Oiwa
Jan 6, 2004·Journal of Neurobiology·Richard B ValleeLora E Barnhart
Feb 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Samara L Reck-Peterson, Ronald D Vale
May 10, 2005·Nature Structural & Molecular Biology·Takahide KonKazuo Sutoh
Jul 21, 2005·The Journal of Biological Chemistry·Peter HöökRichard B Vallee
Nov 1, 2006·Journal of Cell Science·Peter Höök, Richard B Vallee

❮ Previous
Next ❯

Citations

Aug 7, 2012·Structure·Anthony J RobertsStan A Burgess
Feb 12, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Rachel Andorfer, Joshua D Alper
Nov 21, 2009·The EMBO Journal·Anat ShmueliOrly Reiner
Apr 10, 2010·The EMBO Journal·Estelle CrozatDavid J Sherratt
Jul 12, 2011·Angewandte Chemie·Brunilda VeraJames J La Clair
Nov 1, 2006·Journal of Cell Science·Peter Höök, Richard B Vallee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Structural Biology
Stan A Burgess, Peter J Knight
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Andrew P Carter, Ronald D Vale
© 2022 Meta ULC. All rights reserved